Literature DB >> 11100717

In search of the tumour-suppressor functions of BRCA1 and BRCA2.

R Scully1, D M Livingston.   

Abstract

Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. 1). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structure. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.

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Year:  2000        PMID： 11100717      PMCID： PMC2981135          DOI： 10.1038/35044000

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  42 in total

Review 1.  Initiation of genetic recombination and recombination-dependent replication.

Authors:  S C Kowalczykowski
Journal:  Trends Biochem Sci       Date:  2000-04       Impact factor: 13.807

2.  BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Authors:  Y Wang; D Cortez; P Yazdi; N Neff; S J Elledge; J Qin
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

3.  Cancer-susceptibility genes. Gatekeepers and caretakers.

Authors:  K W Kinzler; B Vogelstein
Journal:  Nature       Date:  1997-04-24       Impact factor: 49.962

Review 4.  DNA polymerase stalling, sister chromatid recombination and the BRCA genes.

Authors:  R Scully; N Puget; K Vlasakova
Journal:  Oncogene       Date:  2000-12-11       Impact factor: 9.867

5.  Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74.

Authors:  M Tokunaga; J E Norman; M Asano; S Tokuoka; H Ezaki; I Nishimori; Y Tsuji
Journal:  J Natl Cancer Inst       Date:  1979-06       Impact factor: 13.506

6.  A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

Authors:  T T Paull; E P Rogakou; V Yamazaki; C U Kirchgessner; M Gellert; W M Bonner
Journal:  Curr Biol       Date:  2000 Jul 27-Aug 10       Impact factor: 10.834

7.  Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

Authors:  R S Tibbetts; D Cortez; K M Brumbaugh; R Scully; D Livingston; S J Elledge; R T Abraham
Journal:  Genes Dev       Date:  2000-12-01       Impact factor: 11.361

8.  BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

Authors:  F Le Page; V Randrianarison; D Marot; J Cabannes; M Perricaudet; J Feunteun; A Sarasin
Journal:  Cancer Res       Date:  2000-10-01       Impact factor: 12.701

9.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors:  Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal:  Science       Date:  1994-10-07       Impact factor: 47.728

10.  Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells.

Authors:  A J Fornace
Journal:  Nature       Date:  1983 Aug 11-17       Impact factor: 49.962
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  203 in total

1.  BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets.

Authors:  Timothy K MacLachlan; Rishu Takimoto; Wafik S El-Deiry
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

2.  Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation.

Authors:  B Xu; M B Kastan
Journal:  Mol Cell Biol       Date:  2001-05       Impact factor: 4.272

3.  Tumorigenesis in mice carrying a truncating Brca1 mutation.

Authors:  T Ludwig; P Fisher; S Ganesan; A Efstratiadis
Journal:  Genes Dev       Date:  2001-05-15       Impact factor: 11.361

4.  Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.

Authors:  Kumar Somyajit; Shreelakshmi Subramanya; Ganesh Nagaraju
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

5.  FANCE: the link between Fanconi anaemia complex assembly and activity.

Authors:  Paul Pace; Mark Johnson; Wu Meng Tan; Georgina Mosedale; Chelvin Sng; Maureen Hoatlin; Johan de Winter; Hans Joenje; Fanni Gergely; K J Patel
Journal:  EMBO J       Date:  2002-07-01       Impact factor: 11.598

6.  JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.

Authors:  Yan-Fen Hu; Rong Li
Journal:  Genes Dev       Date:  2002-06-15       Impact factor: 11.361

7.  Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.

Authors:  Gustavo Baldassarre; Sabrina Battista; Barbara Belletti; Sanjay Thakur; Francesca Pentimalli; Francesco Trapasso; Monica Fedele; Giovanna Pierantoni; Carlo M Croce; Alfredo Fusco
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

8.  Menin induces apoptosis in murine embryonic fibroblasts.

Authors:  Robert W Schnepp; Hua Mao; Stephen M Sykes; Wei-Xing Zong; Albert Silva; Ping La; Xianxin Hua
Journal:  J Biol Chem       Date:  2003-12-18       Impact factor: 5.157

9.  Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.

Authors:  Mikhail Lomonosov; Shubha Anand; Mahesh Sangrithi; Rachel Davies; Ashok R Venkitaraman
Journal:  Genes Dev       Date:  2003-12-17       Impact factor: 11.361

10.  Unique tissue-specific level of DNA nucleotide excision repair in primary human mammary epithelial cultures.

Authors:  Jean J Latimer; Tariq Nazir; Lisa C Flowers; Michael J Forlenza; Kelly Beaudry-Rodgers; Crystal M Kelly; Julie A Conte; Kenneth Shestak; Amal Kanbour-Shakir; Stephen G Grant
Journal:  Exp Cell Res       Date:  2003-11-15       Impact factor: 3.905
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