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Literature DB >> 19276123

H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.

Fei Li Kuang¹, Zhonghui Luo, Matthew D Scharff.

Abstract

Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows the same variable (V) region to be expressed with any one of the downstream constant region (C) genes to encode antibodies with many different effector functions. One hypothesis for how CSR is targeted to different C region genes is that histone modifications increase accessibility and/or recruit activation-induced cytosine deaminase (AID) and its associated processes to particular donor and recipient switch regions. In this work, we identified H3 acetyl K9 and H3 trimethyl K9 as histone modifications that correlate with the recombining pair of donor and recipient switch regions. The appearance of H3 trimethyl K9 is surprising because usually it is thought to mark silent genes and heterochromatin. Nevertheless, the time course of appearance of these histone modifications, the regions in IgH they associate with, and their appearance independent of AID damage suggest that both modifications play a role in targeting CSR.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19276123 PMCID： PMC2654022 DOI： 10.1073/pnas.0901368106

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

1. The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

Authors: Sean P Bradley; Denise A Kaminski; Antoine H F M Peters; Thomas Jenuwein; Janet Stavnezer
Journal: J Immunol Date: 2006-07-15 Impact factor: 5.422

Review 2. Accessibility control of V(D)J recombination.

Authors: Robin Milley Cobb; Kenneth J Oestreich; Oleg A Osipovich; Eugene M Oltz
Journal: Adv Immunol Date: 2006 Impact factor: 3.543

Review 3. Chromatin modifications and their function.

Authors: Tony Kouzarides
Journal: Cell Date: 2007-02-23 Impact factor: 41.582

Review 4. Histone lysine demethylases: emerging roles in development, physiology and disease.

Authors: Yang Shi
Journal: Nat Rev Genet Date: 2007-11 Impact factor: 53.242

5. A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.

Authors: Yun Liu; Ramesh Subrahmanyam; Tirtha Chakraborty; Ranjan Sen; Stephen Desiderio
Journal: Immunity Date: 2007-10-11 Impact factor: 31.745

6. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.

Authors: S Lutzker; P Rothman; R Pollock; R Coffman; F W Alt
Journal: Cell Date: 1988-04-22 Impact factor: 41.582

7. Organismal differences in post-translational modifications in histones H3 and H4.

Authors: Benjamin A Garcia; Sandra B Hake; Robert L Diaz; Monika Kauer; Stephanie A Morris; Judith Recht; Jeffrey Shabanowitz; Nilamadhab Mishra; Brian D Strahl; C David Allis; Donald F Hunt
Journal: J Biol Chem Date: 2006-12-28 Impact factor: 5.157

8. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

Authors: Robert Wuerffel; Lili Wang; Fernando Grigera; John Manis; Erik Selsing; Thomas Perlot; Frederick W Alt; Michel Cogne; Eric Pinaud; Amy L Kenter
Journal: Immunity Date: 2007-11-01 Impact factor: 31.745

9. The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

Authors: Kanmin Xue; Cristina Rada; Michael S Neuberger
Journal: J Exp Med Date: 2006-08-07 Impact factor: 14.307

10. DNA rearrangement can account for in vitro switching to IgG1.

Authors: C C Chu; E E Max; W E Paul
Journal: J Exp Med Date: 1993-10-01 Impact factor: 14.307

35 in total

Review 1. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.

Authors: Zhenming Xu; Hong Zan; Egest J Pone; Thach Mai; Paolo Casali
Journal: Nat Rev Immunol Date: 2012-06-25 Impact factor: 53.106

2. 53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination.

Authors: Scott Feldman; Robert Wuerffel; Ikbel Achour; Lili Wang; Phillip B Carpenter; Amy L Kenter
Journal: J Immunol Date: 2017-02-03 Impact factor: 5.422

3. Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination.

Authors: Guideng Li; Zhenming Xu; Clayton A White; Tonika Lam; Egest J Pone; Daniel C Tran; Ken L Hayama; Hong Zan; Paolo Casali
Journal: Cell Rep Date: 2013-10-24 Impact factor: 9.423

4. Elucidation of IgH 3' region regulatory role during class switch recombination via germline deletion.

Authors: Alexis Saintamand; Pauline Rouaud; Faten Saad; Géraldine Rios; Michel Cogné; Yves Denizot
Journal: Nat Commun Date: 2015-05-11 Impact factor: 14.919

5. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.

Authors: Jeremy A Daniel; Margarida Almeida Santos; Zhibin Wang; Chongzhi Zang; Kristopher R Schwab; Mila Jankovic; Darius Filsuf; Hua-Tang Chen; Anna Gazumyan; Arito Yamane; Young-Wook Cho; Hong-Wei Sun; Kai Ge; Weiqun Peng; Michel C Nussenzweig; Rafael Casellas; Gregory R Dressler; Keji Zhao; André Nussenzweig
Journal: Science Date: 2010-07-29 Impact factor: 47.728

10. Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.

Authors: Thach Mai; Egest J Pone; Guideng Li; Tonika S Lam; J'aime Moehlman; Zhenming Xu; Paolo Casali
Journal: J Immunol Date: 2013-07-12 Impact factor: 5.422