Literature DB >> 19275169

Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?

Timothy J Ritchie1, Christopher N Luscombe, Simon J F Macdonald.   

Abstract

From an analysis of calculated physicochemical properties for 81 currently marketed respiratory drugs, compounds administered via the inhaled/intranasal routes have a higher polar surface area, a higher molecular weight, and a trend toward lower lipophilicity, when compared with their orally administered counterparts. Ranges of physicochemical space are described for the 29 drugs administered by the inhaled or intranasal routes.

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Year:  2009        PMID： 19275169     DOI： 10.1021/ci800429e

Source DB:  PubMed          Journal:  J Chem Inf Model        ISSN： 1549-9596            Impact factor:   4.956


  9 in total

Review 1.  The challenge of new drug discovery for tuberculosis.

Authors:  Anil Koul; Eric Arnoult; Nacer Lounis; Jerome Guillemont; Koen Andries
Journal:  Nature       Date:  2011-01-27       Impact factor: 49.962

2.  Lipophilicity prediction of peptides and peptide derivatives by consensus machine learning.

Authors:  Jens-Alexander Fuchs; Francesca Grisoni; Michael Kossenjans; Jan A Hiss; Gisbert Schneider
Journal:  Medchemcomm       Date:  2018-08-22       Impact factor: 3.597

Review 3.  Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery.

Authors:  Sean Ekins; Joel S Freundlich; Inhee Choi; Malabika Sarker; Carolyn Talcott
Journal:  Trends Microbiol       Date:  2010-12-02       Impact factor: 17.079

4.  The rule of five for non-oral routes of drug delivery: ophthalmic, inhalation and transdermal.

Authors:  Young Bin Choy; Mark R Prausnitz
Journal:  Pharm Res       Date:  2010-10-22       Impact factor: 4.200

Review 5.  Target validation: linking target and chemical properties to desired product profile.

Authors:  Paul G Wyatt; Ian H Gilbert; Kevin D Read; Alan H Fairlamb
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

6.  FAF-Drugs3: a web server for compound property calculation and chemical library design.

Authors:  David Lagorce; Olivier Sperandio; Jonathan B Baell; Maria A Miteva; Bruno O Villoutreix
Journal:  Nucleic Acids Res       Date:  2015-04-16       Impact factor: 16.971

7.  Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model.

Authors:  Chris D Edwards; Chris Luscombe; Peter Eddershaw; Edith M Hessel
Journal:  Pharm Res       Date:  2016-07-11       Impact factor: 4.200

8.  Melting Point Distribution Analysis of Globally Approved and Discontinued Drugs: A Research for Improving the Chance of Success of Drug Design and Discovery.

Authors:  Fei Mao; Qingya Kong; Wei Ni; Xiang Xu; Dazheng Ling; Zhengyu Lu; Jian Li
Journal:  ChemistryOpen       Date:  2016-03-21       Impact factor: 2.911

9.  A Free Web-Based Protocol to Assist Structure-Based Virtual Screening Experiments.

Authors:  Nathalie Lagarde; Elodie Goldwaser; Tania Pencheva; Dessislava Jereva; Ilza Pajeva; Julien Rey; Pierre Tuffery; Bruno O Villoutreix; Maria A Miteva
Journal:  Int J Mol Sci       Date:  2019-09-19       Impact factor: 5.923
  9 in total

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