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Literature DB >> 19275156

Dumbbell-like Au-Fe3O4 nanoparticles for target-specific platin delivery.

Abstract

Dumbbell-like Au-Fe(3)O(4) nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin-Au-Fe(3)O(4)-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk-Br3 cells of 1.76 microg of Pt/mL, which is lower than that needed for cisplatin (3.5 microg/mL). The work demonstrates that the dumbbell-like Au-Fe(3)O(4) NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.

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Year: 2009 PMID： 19275156 PMCID： PMC2671397 DOI： 10.1021/ja900790v

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

12 in total

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