PURPOSE: Polymorphic cytochrome P-450 1A2, N-acetyltransferase 1, and 2 are important enzymes involved in the biotransformation of aromatic and heterocyclic amines known as carcinogens for colorectal cancer. A hospital-based study was designed to investigate the association between colorectal cancer and cytochrome P-450 1A2, N-acetyltransferase 1, and N-acetyltransferase 2, with the interaction of meat consumption. METHODS: We genotyped these polymorphisms for 727 colorectal cancer cases and 736 healthy controls. Information on sociodemographic characteristics and diet were ascertained using a structured questionnaire. RESULTS: The colorectal cancer risk was significantly increased in rapid N-acetyltransferase 1 carriers with high white meat consumption (almost every day) compared to those carrying the slow N-acetyltransferase 1 genotype with low white meat consumption (less than once a week, odds ratio, 3.00; 95 percent confidence interval, 1.83-4.92). Furthermore, a gene-gene interaction between cytochrome P-450 1A2*1C and N-acetyltransferase 1 was found and modulated by white meat consumption. CONCLUSIONS: N-acetyltransferase 1 might compete with cytochrome P-450 1A2*1C to increase the colorectal cancer risk in intermediate white meat consumers, whereas the rapid N-acetyltransferase 1 genotype may exert a harmful effect on individuals with high carcinogen exposure.
PURPOSE: Polymorphic cytochrome P-450 1A2, N-acetyltransferase 1, and 2 are important enzymes involved in the biotransformation of aromatic and heterocyclic amines known as carcinogens for colorectal cancer. A hospital-based study was designed to investigate the association between colorectal cancer and cytochrome P-450 1A2, N-acetyltransferase 1, and N-acetyltransferase 2, with the interaction of meat consumption. METHODS: We genotyped these polymorphisms for 727 colorectal cancer cases and 736 healthy controls. Information on sociodemographic characteristics and diet were ascertained using a structured questionnaire. RESULTS: The colorectal cancer risk was significantly increased in rapid N-acetyltransferase 1 carriers with high white meat consumption (almost every day) compared to those carrying the slow N-acetyltransferase 1 genotype with low white meat consumption (less than once a week, odds ratio, 3.00; 95 percent confidence interval, 1.83-4.92). Furthermore, a gene-gene interaction between cytochrome P-450 1A2*1C and N-acetyltransferase 1 was found and modulated by white meat consumption. CONCLUSIONS:N-acetyltransferase 1 might compete with cytochrome P-450 1A2*1C to increase the colorectal cancer risk in intermediate white meat consumers, whereas the rapid N-acetyltransferase 1 genotype may exert a harmful effect on individuals with high carcinogen exposure.
Authors: Leah M Ferrucci; Amanda J Cross; Marc J Gunter; Jiyoung Ahn; Susan T Mayne; Xiaomei Ma; Stephen J Chanock; Meredith Yeager; Barry I Graubard; Sonja I Berndt; Wen-Yi Huang; Richard B Hayes; Rashmi Sinha Journal: World Rev Nutr Diet Date: 2010-04-30 Impact factor: 0.575
Authors: Lea M Ferrucci; Amanda J Cross; Marc J Gunter; Jiyoung Ahn; Susan T Mayne; Xiaomei Ma; Stephen J Chanock; Meredith Yeager; Barry I Graubard; Sonja I Berndt; Wen-Yi Huang; Richard B Hayes; Rashmi Sinha Journal: J Nutrigenet Nutrigenomics Date: 2011-04-06
Authors: Anne M J Gilsing; Sonja I Berndt; Elizabeth H Ruder; Barry I Graubard; Leah M Ferrucci; Laura Burdett; Joel L Weissfeld; Amanda J Cross; Rashmi Sinha Journal: Carcinogenesis Date: 2012-05-02 Impact factor: 4.944
Authors: Hansong Wang; Jennifer F Yamamoto; Christian Caberto; Barbara Saltzman; Robert Decker; Thomas M Vogt; Lance Yokochi; Stephen Chanock; Lynne R Wilkens; Loïc Le Marchand Journal: Carcinogenesis Date: 2010-11-16 Impact factor: 4.944