Literature DB >> 19273687

Bactericidal activity of the combination of levofloxacin with rifampin in experimental prosthetic knee infection in rabbits due to methicillin-susceptible Staphylococcus aureus.

Claudette Muller-Serieys1, Azzam Saleh Mghir, Laurent Massias, Bruno Fantin.   

Abstract

The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.

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Year:  2009        PMID： 19273687      PMCID： PMC2681532          DOI： 10.1128/AAC.01163-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  In vivo antibiotic synergism: contribution of animal models.

Authors:  B Fantin; C Carbon
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

2.  A new model of experimental prosthetic joint infection due to methicillin-resistant Staphylococcus aureus: a microbiologic, histopathologic, and magnetic resonance imaging characterization.

Authors:  N Belmatoug; A C Crémieux; R Bleton; A Volk; A Saleh-Mghir; M Grossin; L Garry; C Carbon
Journal:  J Infect Dis       Date:  1996-08       Impact factor: 5.226

3.  Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty.

Authors:  S Metallidis; D Topsis; J Nikolaidis; E Alexiadou; G Lazaraki; L Grovaris; A Theodoridou; P Nikolaidis
Journal:  J Chemother       Date:  2007-12       Impact factor: 1.714

4.  Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.

Authors:  O Murillo; A Doménech; A Garcia; F Tubau; C Cabellos; F Gudiol; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

5.  Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group.

Authors:  W Zimmerli; A F Widmer; M Blatter; R Frei; P E Ochsner
Journal:  JAMA       Date:  1998-05-20       Impact factor: 56.272

6.  Efficacy of sparfloxacin and autoradiographic diffusion pattern of [14C]Sparfloxacin in experimental Staphylococcus aureus joint prosthesis infection.

Authors:  A C Crémieux; A S Mghir; R Bleton; M Manteau; N Belmatoug; L Massias; L Garry; N Sales; B Mazière; C Carbon
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

7.  Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus.

Authors:  J C Lucet; M Herrmann; P Rohner; R Auckenthaler; F A Waldvogel; D P Lew
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

8.  Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials.

Authors:  S L Preston; G L Drusano; A L Berman; C L Fowler; A T Chow; B Dornseif; V Reichl; J Natarajan; M Corrado
Journal:  JAMA       Date:  1998-01-14       Impact factor: 56.272

9.  Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants.

Authors:  M Drancourt; A Stein; J N Argenson; A Zannier; G Curvale; D Raoult
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

Review 10.  Lessons learned from animal models of osteomyelitis.

Authors:  C W Norden
Journal:  Rev Infect Dis       Date:  1988 Jan-Feb
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  2 in total

Review 1.  A systematic review of animal models for Staphylococcus aureus osteomyelitis.

Authors:  W Reizner; J G Hunter; N T O'Malley; R D Southgate; E M Schwarz; S L Kates
Journal:  Eur Cell Mater       Date:  2014-03-25       Impact factor: 3.942

2.  Orthopaedic Implant-Associated Staphylococcal Infections: A Critical Reappraisal of Unmet Clinical Needs Associated with the Implementation of the Best Antibiotic Choice.

Authors:  Milo Gatti; Simona Barnini; Fabio Guarracino; Eva Maria Parisio; Michele Spinicci; Bruno Viaggi; Sara D'Arienzo; Silvia Forni; Angelo Galano; Fabrizio Gemmi
Journal:  Antibiotics (Basel)       Date:  2022-03-17
  2 in total

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