Literature DB >> 19267375

A highly potent and cellularly active beta-peptidic inhibitor of the p53/hDM2 interaction.

Martin Hintersteiner1, Thierry Kimmerlin, Geraldine Garavel, Thorsten Schindler, Roman Bauer, Nicole-Claudia Meisner, Jan-Marcus Seifert, Volker Uhl, Manfred Auer.   

Abstract

New and improved: The incorporation of a 6-chlorotryptophan (6-Cl-Trp) into a beta-peptide (M)-3(14) helix leads to a high-affinity hDM2 inhibitor, as demonstrated by fluorescence fluctuation analysis at single molecule resolution. When conjugated to penetratin, the newly derived hDM2 binder specifically inhibits tumour cell growth in vitro.

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Year:  2009        PMID： 19267375     DOI： 10.1002/cbic.200800803

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  7 in total

1.  Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions.

Authors:  Nam Tran-Hoang; Thomas Kodadek
Journal:  ACS Comb Sci       Date:  2018-01-24       Impact factor: 3.784

Review 2.  Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

Authors:  Valeria Azzarito; Kérya Long; Natasha S Murphy; Andrew J Wilson
Journal:  Nat Chem       Date:  2013-03       Impact factor: 24.427

3.  Characteristic structural parameters for the γ-peptide 14-helix: importance of subunit preorganization.

Authors:  Li Guo; Weicheng Zhang; Andrew G Reidenbach; Michael W Giuliano; Ilia A Guzei; Lara C Spencer; Samuel H Gellman
Journal:  Angew Chem Int Ed Engl       Date:  2011-05-12       Impact factor: 15.336

4.  An ultrahigh affinity d-peptide antagonist Of MDM2.

Authors:  Changyou Zhan; Le Zhao; Xiaoli Wei; Xueji Wu; Xishan Chen; Weirong Yuan; Wei-Yue Lu; Marzena Pazgier; Wuyuan Lu
Journal:  J Med Chem       Date:  2012-06-22       Impact factor: 7.446

5.  Label transfer reagents to probe p38 MAPK binding partners.

Authors:  Simeon S Andrews; Zachary B Hill; B Gayani K Perera; Dustin J Maly
Journal:  Chembiochem       Date:  2013-01-14       Impact factor: 3.164

6.  Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening.

Authors:  Martin Hintersteiner; Andrew J Knox; Gemma Mudd; Manfred Auer
Journal:  J Chem Biol       Date:  2012-01-03

Review 7.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Authors:  Marta Pelay-Gimeno; Adrian Glas; Oliver Koch; Tom N Grossmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-26       Impact factor: 15.336
  7 in total

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