| Literature DB >> 19266331 |
Valérie Gailus-Durner1, Helmut Fuchs, Thure Adler, Antonio Aguilar Pimentel, Lore Becker, Ines Bolle, Julia Calzada-Wack, Claudia Dalke, Nicole Ehrhardt, Barbara Ferwagner, Wolfgang Hans, Sabine M Hölter, Gabriele Hölzlwimmer, Marion Horsch, Anahita Javaheri, Magdalena Kallnik, Eva Kling, Christoph Lengger, Corinna Mörth, Ilona Mossbrugger, Beatrix Naton, Cornelia Prehn, Oliver Puk, Birgit Rathkolb, Jan Rozman, Anja Schrewe, Frank Thiele, Jerzy Adamski, Bernhard Aigner, Heidrun Behrendt, Dirk H Busch, Jack Favor, Jochen Graw, Gerhard Heldmaier, Boris Ivandic, Hugo Katus, Martin Klingenspor, Thomas Klopstock, Elisabeth Kremmer, Markus Ollert, Leticia Quintanilla-Martinez, Holger Schulz, Eckhard Wolf, Wolfgang Wurst, Martin Hrabé de Angelis.
Abstract
With the completion of the mouse genome sequence an essential task for biomedical sciences in the twenty-first century will be the generation and functional analysis of mouse models for every gene in the mammalian genome. More than 30,000 mutations in ES cells will be engineered and thousands of mouse disease models will become available over the coming years by the collaborative effort of the International Mouse Knockout Consortium. In order to realize the full value of the mouse models proper characterization, archiving and dissemination of mouse disease models to the research community have to be performed. Phenotyping centers (mouse clinics) provide the necessary capacity, broad expertise, equipment, and infrastructure to carry out large-scale systemic first-line phenotyping. Using the example of the German Mouse Clinic (GMC) we will introduce the reader to the different aspects of the organization of a mouse clinic and present selected methods used in first-line phenotyping.Entities:
Mesh：
Year: 2009 PMID： 19266331 DOI： 10.1007/978-1-59745-471-1_25
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745