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Literature DB >> 19264842

PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration.

Siwei Li¹, Qian Wang, Yi Wang, Xinmei Chen, Zhixiang Wang.

Abstract

It is well established that epidermal growth factor (EGF) induces the cytoskeleton reorganization and cell migration through two major signaling cascades: phospholipase C-gamma1 (PLC-gamma1) and Rho GTPases. However, little is known about the cross talk between PLC-gamma1 and Rho GTPases. Here we showed that PLC-gamma1 forms a complex with Rac1 in response to EGF. This interaction is direct and mediated by PLC-gamma1 Src homology 3 (SH3) domain and Rac1 (106)PNTP(109) motif. This interaction is critical for EGF-induced Rac1 activation in vivo, and PLC-gamma1 SH3 domain is actually a potent and specific Rac1 guanine nucleotide exchange factor in vitro. We have also demonstrated that the interaction between PLC-gamma1 SH3 domain and Rac1 play a significant role in EGF-induced F-actin formation and cell migration. We conclude that PLC-gamma1 and Rac1 coregulate EGF-induced cell cytoskeleton remodeling and cell migration by a direct functional interaction.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2009 PMID： 19264842 PMCID： PMC5419285 DOI： 10.1210/me.2008-0368

Source DB: PubMed Journal: Mol Endocrinol ISSN： 0888-8809

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