| Literature DB >> 19264509 |
Luiz Carlos Gebrim1, Silvana Marcussi, Danilo L Menaldo, Carla S R de Menezes, Auro Nomizo, Amélia Hamaguchi, Elisângela P Silveira-Lacerda, Maria Inês Homsi-Brandeburgo, Suely V Sampaio, Andreimar M Soares, Veridiana M Rodrigues.
Abstract
The present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-I and its cationic synthetic peptide derived from the 115-129 C-terminal region. BPB-BthTX-I presented cytotoxicity of 10-40% on different tumor cell lines, which were also susceptible to the lytic action of the synthetic peptide. Injection of the modified protein or the peptide in mice, 5 days after transplantation of S180 tumor cells, reduced 30 and 36% of the tumor size on day 14th and 76 and 79% on day 60th, respectively, when compared to the untreated control group. Thus, these antitumor properties might be of interest in the development of therapeutic strategies against cancer.Entities:
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Year: 2009 PMID： 19264509 DOI： 10.1016/j.biologicals.2009.01.010
Source DB: PubMed Journal: Biologicals ISSN： 1045-1056 Impact factor: 1.856