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Literature DB >> 19259284

Cancer stem cells, endothelial progenitors, and mesenchymal stem cells: "seed and soil" theory revisited.

Edward H Lin¹, Yixing Jiang, Yanhong Deng, Ritu Lapsiwala, Tongyu Lin, C Anthony Blau.

Abstract

Isolation of putative cancer stem cells (CSCs) in various tumors has generated much excitement among researchers who consider these cells the potential "culprits" behind resistance to conventional therapy. Both cancer and cardiovascular disease are believed to be stem cell disorders involving circulating endothelial progenitors (CEPs) and mesenchymal stem cells (MSCs). CD133 and CD44, markers of CSCs in many tumors, also enrich CEPs and MSCs, respectively. We propose an integrated tumorigenesis model that involves all three interdependent stem cell (CSC, CEP, MSC) compartments by revisiting the "seed and soil" model. Developing therapeutics that can effectively target CSCs and spare normal cardiovascular tissue will remain a challenge. Preliminary laboratory and clinical data on monitoring and targeting colon CSCs, using such a modeling system, are discussed.

Entities: Disease Gene

Year: 2008 PMID： 19259284 PMCID： PMC2632830

Source DB: PubMed Journal: Gastrointest Cancer Res ISSN： 1934-7820

117 in total

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Journal: Nature Date: 2006-12-07 Impact factor: 49.962

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Authors: Yoshihiro Yamada; Shin-ichiro Yokoyama; Xiang-Di Wang; Noboru Fukuda; Nobuyuki Takakura
Journal: Stem Cells Date: 2007-02-08 Impact factor: 6.277

3. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors.

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Journal: Blood Date: 2000-02-01 Impact factor: 22.113

4. CD133+ renal progenitor cells contribute to tumor angiogenesis.

Authors: Stefania Bruno; Benedetta Bussolati; Cristina Grange; Federica Collino; Manuela Efrem Graziano; Ugo Ferrando; Giovanni Camussi
Journal: Am J Pathol Date: 2006-12 Impact factor: 4.307

5. Salivary soluble CD44: a potential molecular marker for head and neck cancer.

Authors: Elizabeth J Franzmann; Erika P Reategui; Kermit L Carraway; Kara L Hamilton; Donald T Weed; W Jarrard Goodwin
Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-03 Impact factor: 4.254

6. Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non-Hodgkin's lymphoma.

Authors: K Sasaki; N Niitsu
Journal: Eur J Haematol Date: 2000-09 Impact factor: 2.997

7. Significance of circulating endothelial progenitor cells in hepatocellular carcinoma.

Authors: Joanna W Y Ho; Roberta W C Pang; Cecilia Lau; Chris K Sun; Wan Ching Yu; Sheung Tat Fan; Ronnie T P Poon
Journal: Hepatology Date: 2006-10 Impact factor: 17.425

8. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.

Authors: Herbert Hurwitz; Louis Fehrenbacher; William Novotny; Thomas Cartwright; John Hainsworth; William Heim; Jordan Berlin; Ari Baron; Susan Griffing; Eric Holmgren; Napoleone Ferrara; Gwen Fyfe; Beth Rogers; Robert Ross; Fairooz Kabbinavar
Journal: N Engl J Med Date: 2004-06-03 Impact factor: 91.245

9. Purification and characterization of mouse hematopoietic stem cells.

Authors: G J Spangrude; S Heimfeld; I L Weissman
Journal: Science Date: 1988-07-01 Impact factor: 47.728

10. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.

Authors: Luis A Ortiz; Frederica Gambelli; Christine McBride; Dina Gaupp; Melody Baddoo; Naftali Kaminski; Donald G Phinney
Journal: Proc Natl Acad Sci U S A Date: 2003-06-18 Impact factor: 12.779

11 in total

1. Colon cancer stem cells: a new target in the war against cancer.

Authors: Heinz-Josef Lenz
Journal: Gastrointest Cancer Res Date: 2008-07

2. The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade.

Authors: Xiao-Feng Le; Omar Merchant; Robert C Bast; George A Calin
Journal: Cancer Microenviron Date: 2010-02-23

3. Mesenchymal stem cells maintain the stemness of colon cancer stem cells via interleukin-8/mitogen-activated protein kinase signaling pathway.

Authors: Xiaoying Ma; Jiajun Liu; Xiaotong Yang; Kai Fang; Peiyong Zheng; Xin Liang; Jianwen Liu
Journal: Exp Biol Med (Maywood) Date: 2020-03-02

Review 4. Rational therapeutic options for patients with myeloproliferative neoplasms.

Authors: Ronald Hoffman
Journal: Trans Am Clin Climatol Assoc Date: 2011

5. Role of treatment in the appearance and selection of BCR-ABL1 kinase domain mutations.

Authors: Filip Razga; Tomas Jurcek; Daniela Zackova; Dana Dvorakova; Martina Toskova; Ivana Jeziskova; Jiri Mayer; Zdenek Racil
Journal: Mol Diagn Ther Date: 2012-08-01 Impact factor: 4.074

6. Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis.

Authors: Jaya Mallela; Sowndharya Ravi; Frantz Jean Louis; Bianca Mulaney; Michael Cheung; Ujjwala Sree Garapati; Vignesh Chinnasamy; Chunyan Wang; Srinivas Nagaraj; Shyam S Mohapatra; Subhra Mohapatra
Journal: Stem Cells Date: 2013-07 Impact factor: 6.277

7. Proteomic definitions of mesenchymal stem cells.

Authors: Martin H Maurer
Journal: Stem Cells Int Date: 2011-03-03 Impact factor: 5.443

8. A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells.

Authors: Wenhui Zhang; Huanhuan Yang; Yanna Zhang; Yanan Lu; Tianlin Zhou; Meng Li; Yanjun Wen; Xiaojuan Lin; Rong Xiang; Xiancheng Chen
Journal: Oncotarget Date: 2015-12-01

9. The First Study Evaluating the Safety of Pre-Surgery Administration of Metformin in Patients with Colorectal and other Gastrointestinal Cancers and Effect on Cancer Stem Cells.

Authors: Muhammad Wasif Saif; Shrikar Rajagopal; Jennifer Caplain; Martin D Goodman; Daniel Popowich; Bruce A Orkin; Philip N Tsichlis; Robert Martell
Journal: Cancer Med J Date: 2021-02-19

10. Wnt-Responsive Stem Cell Fates in the Oral Mucosa.

Authors: Xue Yuan; Quanchen Xu; Xiaohui Zhang; Lauren A Van Brunt; Pavla Ticha; Jill A Helms
Journal: iScience Date: 2019-10-10