Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography.

We demonstrate and compare two image processing methods for visualization and analysis of three-dimensional optical coherence tomography (OCT) data acquired in eyes with different retinal pathologies. A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps. We compare the applicability of the two methods to the diagnosis of retinal diseases and their progression. The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 microm) spectral OCT prototype instrument operating in the ophthalmology clinic.