BACKGROUND: Doppler echocardiogram is useful for the evaluation of anatomical and functional changes in late myocardial infarction (MI) in rats. However, no studies have evaluated the prognostic value of echocardiographic parameters 1 week after MI. METHODS AND RESULTS: Doppler echocardiogram was performed in 84 female Wistar rats 1 week after MI to determine infarction size, left chambers dimensions, fractional area change (FAC) of the left ventricle (LV), mitral inflow and tissue Doppler, myocardial performance index (MPI), and signs of pulmonary hypertension. The 365-day follow-up showed 53.6% mortality rate. Nonsurvivors showed larger (P < .05) MI size and cavity dimensions, poorer diastolic and systolic function, and higher frequency of pulmonary hypertension. Parameters at early stage of MI associated with higher mortality risk by Cox multivariate regression model were FAC <or=37% (relative risk [RR] 3.78, 95% CI, 1.50-9.53), MPI >or=0.60 (RR 3.49, 95% CI, 1.80-6.76), LV systolic area >or=0.26 cm(2) (RR 4.38, 95% CI, 1.88-10.21), E/E' ratio >or=20.3 (RR 2.12, 95% CI, 1.15-4.34), and E/A ratio associated with FAC (RR 2.99, 95% CI, 1.44-6.18). CONCLUSION: Some diastolic and systolic Doppler echocardiographic parameters in rats may be able to predict late mortality risk after MI.
BACKGROUND: Doppler echocardiogram is useful for the evaluation of anatomical and functional changes in late myocardial infarction (MI) in rats. However, no studies have evaluated the prognostic value of echocardiographic parameters 1 week after MI. METHODS AND RESULTS: Doppler echocardiogram was performed in 84 female Wistar rats 1 week after MI to determine infarction size, left chambers dimensions, fractional area change (FAC) of the left ventricle (LV), mitral inflow and tissue Doppler, myocardial performance index (MPI), and signs of pulmonary hypertension. The 365-day follow-up showed 53.6% mortality rate. Nonsurvivors showed larger (P < .05) MI size and cavity dimensions, poorer diastolic and systolic function, and higher frequency of pulmonary hypertension. Parameters at early stage of MI associated with higher mortality risk by Cox multivariate regression model were FAC <or=37% (relative risk [RR] 3.78, 95% CI, 1.50-9.53), MPI >or=0.60 (RR 3.49, 95% CI, 1.80-6.76), LV systolic area >or=0.26 cm(2) (RR 4.38, 95% CI, 1.88-10.21), E/E' ratio >or=20.3 (RR 2.12, 95% CI, 1.15-4.34), and E/A ratio associated with FAC (RR 2.99, 95% CI, 1.44-6.18). CONCLUSION: Some diastolic and systolic Doppler echocardiographic parameters in rats may be able to predict late mortality risk after MI.
Authors: Ednei Luiz Antonio; Andrey Jorge Serra; Alexandra Alberta dos Santos; Stella Sousa Vieira; Jairo Montemor Augusto Silva; Amanda Yoshizaki; Renato Rodrigues Sofia; Paulo José Ferreira Tucci Journal: Rev Bras Cir Cardiovasc Date: 2015 Jan-Mar
Authors: Martha Trindade Manchini; Andrey Jorge Serra; Regiane dos Santos Feliciano; Eduardo Tadeu Santana; Ednei Luis Antônio; Paulo de Tarso Camillo de Carvalho; Jairo Montemor; Renato Oliveira Crajoinas; Adriana Castello Costa Girardi; Paulo José Ferreira Tucci; José Antônio Silva Journal: PLoS One Date: 2014-07-03 Impact factor: 3.240