BACKGROUND: Genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease. METHODS: In this study, we examined for the first time the effect of these variants in 2918 adults in a longitudinal birth cohort, the British National Survey of Health and Development, where there are extensive life style, developmental and environmental data. We examine two IL13 single nucleotide polymorphisms (SNPs) IL13 rs20541 (R110Q) and rs1800925 (-1024C>T) and one IL4 SNP, rs2070874 (-33C>T) with likely function. RESULTS: We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth. IL13 rs20541 does however act as a confounder for the IL13 rs1800925 associations, meaning that there is no statistical support for rs1800925 having an independent effect. There is nevertheless evidence for interaction between smoking and rs1800925, with allergy as outcome. None of the SNPs showed association with measures of lung function, nor any interaction with the effect of smoking on lung function. CONCLUSION: In a longitudinal population cohort we have established a role for polymorphism of IL13 in determining susceptibility to both atopy and asthma.
BACKGROUND: Genetic variants of the two adjacent genes, IL13 and IL4 have frequently been reported as being associated with susceptibility to atopy and asthma, both in adults and children, and some studies also suggest association with lung function and chronic obstructive pulmonary disease. METHODS: In this study, we examined for the first time the effect of these variants in 2918 adults in a longitudinal birth cohort, the British National Survey of Health and Development, where there are extensive life style, developmental and environmental data. We examine two IL13 single nucleotide polymorphisms (SNPs) IL13rs20541 (R110Q) and rs1800925 (-1024C>T) and one IL4 SNP, rs2070874 (-33C>T) with likely function. RESULTS: We show that IL13rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth. IL13rs20541 does however act as a confounder for the IL13rs1800925 associations, meaning that there is no statistical support for rs1800925 having an independent effect. There is nevertheless evidence for interaction between smoking and rs1800925, with allergy as outcome. None of the SNPs showed association with measures of lung function, nor any interaction with the effect of smoking on lung function. CONCLUSION: In a longitudinal population cohort we have established a role for polymorphism of IL13 in determining susceptibility to both atopy and asthma.
Authors: Lisa G Johnson; Stephen M Schwartz; Mari Malkki; Qin Du; Effie W Petersdorf; Denise A Galloway; Margaret M Madeleine Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-11-11 Impact factor: 4.254
Authors: Lisa J Martin; Hua He; Margaret H Collins; J Pablo Abonia; Joceyln M Biagini Myers; Michael Eby; Hanna Johansson; Leah C Kottyan; Gurjit K Khurana Hershey; Marc E Rothenberg Journal: J Allergy Clin Immunol Date: 2017-11-10 Impact factor: 10.793
Authors: Sven Michel; Liming Liang; Martin Depner; Norman Klopp; Andreas Ruether; Ashish Kumar; Michaela Schedel; Christian Vogelberg; Erika von Mutius; Andrea von Berg; Albrecht Bufe; Ernst Rietschel; Andrea Heinzmann; Otto Laub; Burkhard Simma; Thomas Frischer; Jon Genuneit; Ivo G Gut; Stefan Schreiber; Mark Lathrop; Thomas Illig; Michael Kabesch Journal: PLoS One Date: 2010-11-12 Impact factor: 3.240