BACKGROUND: Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI. MATERIALS AND METHODS: A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted. CONCLUSION: Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.
BACKGROUND: Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI. MATERIALS AND METHODS: A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted. CONCLUSION: Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.
Authors: Veronica Popescu; Roel Klaver; Adriaan Versteeg; Pieter Voorn; Jos W R Twisk; Frederik Barkhof; Jeroen J G Geurts; Hugo Vrenken Journal: Hum Brain Mapp Date: 2016-03-04 Impact factor: 5.038
Authors: Aikaterini Kotrotsou; David A Bennett; Julie A Schneider; Robert J Dawe; Tom Golak; Sue E Leurgans; Lei Yu; Konstantinos Arfanakis Journal: Magn Reson Med Date: 2013-02-25 Impact factor: 4.668
Authors: Martina Absinta; Govind Nair; Massimo Filippi; Abhik Ray-Chaudhury; Maria I Reyes-Mantilla; Carlos A Pardo; Daniel S Reich Journal: J Neuropathol Exp Neurol Date: 2014-08 Impact factor: 3.685
Authors: Cristina Granziera; Jens Wuerfel; Frederik Barkhof; Massimiliano Calabrese; Nicola De Stefano; Christian Enzinger; Nikos Evangelou; Massimo Filippi; Jeroen J G Geurts; Daniel S Reich; Maria A Rocca; Stefan Ropele; Àlex Rovira; Pascal Sati; Ahmed T Toosy; Hugo Vrenken; Claudia A M Gandini Wheeler-Kingshott; Ludwig Kappos Journal: Brain Date: 2021-06-22 Impact factor: 13.501