Literature DB >> 19252834

Generation and selection of rabbit antibody libraries by phage display.

Christoph Rader1.   

Abstract

The rabbit antibody repertoire is an exceptional source for both polyclonal antibodies (pAbs) and monoclonal antibodies (mAbs) that combine high specificity with high avidity and affinity, respectively. In contrast to rabbit pAbs, which have been utilized for decades, rabbit mAbs are defined reagents with infinite supply, prompting considerable interest in recent years. Phage-display technology based on chimeric rabbit/human Fab libraries allows the selection of rabbit mAbs that cross-react with mouse and human antigens while maintaining high affinity and specificity.

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Year:  2009        PMID： 19252834     DOI： 10.1007/978-1-59745-554-1_5

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  16 in total

1.  A Sortase A Programmable Phage Display Format for Improved Panning of Fab Antibody Libraries.

Authors:  Henry D Wilson; Xiuling Li; Haiyong Peng; Christoph Rader
Journal:  J Mol Biol       Date:  2018-09-11       Impact factor: 5.469

2.  Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity.

Authors:  Ka Yin Kwong; Sivasubramanian Baskar; Hua Zhang; Crystal L Mackall; Christoph Rader
Journal:  J Mol Biol       Date:  2008-09-16       Impact factor: 5.469

3.  Isolation of rabbit single domain antibodies to B7-H3 via protein immunization and phage display.

Authors:  Ruonan Feng; Ruixue Wang; Jessica Hong; Christopher M Dower; Brad St Croix; Mitchell Ho
Journal:  Antib Ther       Date:  2020-02-17

4.  Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy.

Authors:  Xiaolei Zhuang; Norman R Watts; Ira W Palmer; Joshua D Kaufman; Altaira D Dearborn; Joni L Trenbeath; Elif Eren; Alasdair C Steven; Christoph Rader; Paul T Wingfield
Journal:  J Biol Chem       Date:  2017-08-23       Impact factor: 5.157

Review 5.  An overview of the lagomorph immune system and its genetic diversity.

Authors:  Ana Pinheiro; Fabiana Neves; Ana Lemos de Matos; Joana Abrantes; Wessel van der Loo; Rose Mage; Pedro José Esteves
Journal:  Immunogenetics       Date:  2015-09-23       Impact factor: 2.846

6.  Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility.

Authors:  Haiyong Peng; Thomas Nerreter; Jing Chang; Junpeng Qi; Xiuling Li; Pabalu Karunadharma; Gustavo J Martinez; Mohammad Fallahi; Jo Soden; Jim Freeth; Roger R Beerli; Ulf Grawunder; Michael Hudecek; Christoph Rader
Journal:  J Mol Biol       Date:  2017-08-14       Impact factor: 5.469

7.  The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing.

Authors:  Sreekumar Kodangattil; Christine Huard; Cindy Ross; Jian Li; Huilan Gao; Alessandro Mascioni; Santosh Hodawadekar; Snehal Naik; Jessica Min-debartolo; Alberto Visintin; Juan C Almagro
Journal:  MAbs       Date:  2014-01-30       Impact factor: 5.857

8.  Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication.

Authors:  Frederico Aires da Silva; Min Li; Sylvie Rato; Sara Maia; Rui Malhó; Kylie Warren; David Harrich; Robert Craigie; Carlos Barbas; Joao Goncalves
Journal:  Biotechnol Appl Biochem       Date:  2012-10-10       Impact factor: 2.431

9.  Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.

Authors:  Rebecca S Goydel; Justus Weber; Haiyong Peng; Junpeng Qi; Jo Soden; Jim Freeth; HaJeung Park; Christoph Rader
Journal:  J Biol Chem       Date:  2020-03-19       Impact factor: 5.157

10.  Generation and use of antibody fragments for structural studies of proteins refractory to crystallization.

Authors:  Stephen J Stahl; Norman R Watts; Paul T Wingfield
Journal:  Methods Mol Biol       Date:  2014
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