OBJECTIVE: To verify the relationships between the values of plasma glucose (PG) and hemoglobin A(1c)(HbA(1c)) in type 2 diabetic outpatients. METHODS: The pre- and postbreakfast PG and HbA(1c) values were monitored every month for 44-90 months. The single regression lines between the values of PG and HbA(1c) were compared for the slopes and intercepts on the designated ordinates of the regression lines. PATIENTS OR MATERIALS: Nine patients of type 2 diabetes not treated with insulin: three males and six females, aged 43-79 years participated. RESULTS: The HbA(1c) level was combined with the pre- and postbreakfast PG values obtained at one month prior to its determination, because the combinations were correlated most strongly. The slopes of the regression line ranged from 0.33-0.50%/mmol/L and the intercepts at PG level equal to 9.6 mmol/L ranged from 6.95-9.77% in the relationship between the values of 1-month earlier prebreakfast PG and HbA(1c). Twenty-eight pairs had significantly different intercepts. Meanwhile, there was no pair that had significantly different slopes. Similar results were obtained in the relationship between the values of 1-month earlier postbreakfast PG and HbA(1c). CONCLUSION: There was interindividual divergence of the regression lines which was due to the difference in the intercepts but not the slopes.
OBJECTIVE: To verify the relationships between the values of plasma glucose (PG) and hemoglobin A(1c)(HbA(1c)) in type 2 diabetic outpatients. METHODS: The pre- and postbreakfast PG and HbA(1c) values were monitored every month for 44-90 months. The single regression lines between the values of PG and HbA(1c) were compared for the slopes and intercepts on the designated ordinates of the regression lines. PATIENTS OR MATERIALS: Nine patients of type 2 diabetes not treated with insulin: three males and six females, aged 43-79 years participated. RESULTS: The HbA(1c) level was combined with the pre- and postbreakfast PG values obtained at one month prior to its determination, because the combinations were correlated most strongly. The slopes of the regression line ranged from 0.33-0.50%/mmol/L and the intercepts at PG level equal to 9.6 mmol/L ranged from 6.95-9.77% in the relationship between the values of 1-month earlier prebreakfast PG and HbA(1c). Twenty-eight pairs had significantly different intercepts. Meanwhile, there was no pair that had significantly different slopes. Similar results were obtained in the relationship between the values of 1-month earlier postbreakfast PG and HbA(1c). CONCLUSION: There was interindividual divergence of the regression lines which was due to the difference in the intercepts but not the slopes.
Authors: James M Hempe; Shuqian Liu; Leann Myers; Robert J McCarter; John B Buse; Vivian Fonseca Journal: Diabetes Care Date: 2015-04-17 Impact factor: 19.112
Authors: Maria Adelaide Marini; Teresa Vanessa Fiorentino; Elena Succurro; Elisabetta Pedace; Francesco Andreozzi; Angela Sciacqua; Francesco Perticone; Giorgio Sesti Journal: PLoS One Date: 2017-04-20 Impact factor: 3.240