Literature DB >> 19249673

Taking the stress out of melanoma.

Matthew J Martin1, David Carling, Richard Marais.   

Abstract

A recent study published in Molecular Cell describes a mechanism whereby oncogenic BRAF inhibits AMPK in melanoma cells. This may explain why cancer cells expressing oncogenic BRAF grow under conditions of metabolic stress and may provide new therapeutic opportunities to treat this life-threatening disease.

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Year:  2009        PMID： 19249673     DOI： 10.1016/j.ccr.2009.02.006

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  5 in total

1.  DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Authors:  A Mitra; M E Menezes; L K Pannell; M S Mulekar; R E Honkanen; L A Shevde; R S Samant
Journal:  Oncogene       Date:  2012-01-23       Impact factor: 9.867

2.  AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.

Authors:  Takeshi Namiki; Atsushi Tanemura; Julio C Valencia; Sergio G Coelho; Thierry Passeron; Masakazu Kawaguchi; Wilfred D Vieira; Masashi Ishikawa; Wataru Nishijima; Toshiyuki Izumo; Yasuhiko Kaneko; Ichiro Katayama; Yuji Yamaguchi; Lanlan Yin; Eric C Polley; Hongfang Liu; Yutaka Kawakami; Yoshinobu Eishi; Eishi Takahashi; Hiroo Yokozeki; Vincent J Hearing
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-01       Impact factor: 11.205

3.  MiR-1179 represses cell proliferation, migration and invasion of hepatocellular carcinoma through suppression of NUAK2.

Authors:  Dejun Wang; Xue Song; Nan Zhang; Yesong Guo
Journal:  Am J Transl Res       Date:  2022-01-15       Impact factor: 4.060

4.  The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.

Authors:  Soouk Kang; Jong-Eun Kim; Nu Ry Song; Sung Keun Jung; Mee Hyun Lee; Jun Seong Park; Myeong-Hun Yeom; Ann M Bode; Zigang Dong; Ki Won Lee
Journal:  PLoS One       Date:  2014-08-19       Impact factor: 3.240

5.  Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin.

Authors:  Chen-Chieh Yang; Shun-Fu Chang; Jian-Kang Chao; Yi-Liang Lai; Wei-En Chang; Wen-Hsiu Hsu; Wu-Hsien Kuo
Journal:  BMC Cancer       Date:  2014-02-20       Impact factor: 4.430
  5 in total

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