Yan Fang1, Beihua Kong, Qifeng Yang, Daoxin Ma, Xun Qu. 1. Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji'nan 250012, Shandong, People's Republic of China.
Abstract
BACKGROUND: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. METHODS: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. RESULTS: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092-7.011). CONCLUSIONS: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.
BACKGROUND: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. METHODS: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. RESULTS: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092-7.011). CONCLUSIONS: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.
Authors: Lukasz F Grochola; Jorge Zeron-Medina; Sophie Mériaux; Gareth L Bond Journal: Cold Spring Harb Perspect Biol Date: 2009-12-09 Impact factor: 10.005
Authors: Stian Knappskog; Liv B Gansmo; Khadizha Dibirova; Andres Metspalu; Cezary Cybulski; Paolo Peterlongo; Lauri Aaltonen; Lars Vatten; Pål Romundstad; Kristian Hveem; Peter Devilee; Gareth D Evans; Dongxin Lin; Guy Van Camp; Vangelis G Manolopoulos; Ana Osorio; Lili Milani; Tayfun Ozcelik; Pierre Zalloua; Francis Mouzaya; Elena Bliznetz; Elena Balanovska; Elvira Pocheshkova; Vaidutis Kučinskas; Lubov Atramentova; Pagbajabyn Nymadawa; Konstantin Titov; Maria Lavryashina; Yuldash Yusupov; Natalia Bogdanova; Sergey Koshel; Jorge Zamora; David C Wedge; Deborah Charlesworth; Thilo Dörk; Oleg Balanovsky; Per E Lønning Journal: Oncotarget Date: 2014-09-30