Literature DB >> 19240852

Inhibition of thrombin and factor Xa by Fucus evanescens fucoidan and its modified analogs.

E S Lapikova1, N N Drozd, A S Tolstenkov, V A Makarov, T N Zvyagintseva, N M Shevchenko, I U Bakunina, N N Besednova, T A Kuznetsova.   

Abstract

Specimens of fucoidan extracted from Fucus evanescens were purified from protein and polyphenols, deacetylated and depolymerized by fucoidanase for evaluation of their biological activity. Deacetylation did not modify the capacity of fucoidan to inhibit thrombin and factor Xa, while purification from protein and polyphenols reduced this capacity. Depolymerization of fucoidan increased its capacity to inhibit thrombin mainly through heparin cofactor II. All the studied specimens formed complexes with protamine sulfate.

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Year:  2008        PMID： 19240852     DOI： 10.1007/s10517-008-0267-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

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Journal:  Molecules       Date:  2021-04-29       Impact factor: 4.411

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Review 3.  Phycochemical Constituents and Biological Activities of Fucus spp.

Authors:  Marcelo D Catarino; Artur M S Silva; Susana M Cardoso
Journal:  Mar Drugs       Date:  2018-07-27       Impact factor: 5.118

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Journal:  Mar Drugs       Date:  2019-12-06       Impact factor: 5.118

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8.  Novel Enzyme Actions for Sulphated Galactofucan Depolymerisation and a New Engineering Strategy for Molecular Stabilisation of Fucoidan Degrading Enzymes.

Authors:  Hang T T Cao; Maria D Mikkelsen; Mateusz J Lezyk; Ly M Bui; Van T T Tran; Artem S Silchenko; Mikhail I Kusaykin; Thinh D Pham; Bang H Truong; Jesper Holck; Anne S Meyer
Journal:  Mar Drugs       Date:  2018-11-01       Impact factor: 5.118
  8 in total

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