Literature DB >> 19236877

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.

Max Crispin1, Thomas A Bowden, Charlotte H Coles, Karl Harlos, A Radu Aricescu, David J Harvey, David I Stuart, E Yvonne Jones.   

Abstract

Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions. The crystal structure of a biosynthetic intermediate of human IgG1, bearing immature oligomannose-type glycans and reported to display increased antibody-dependent cellular cytotoxicity, demonstrates that glycan engineering can bias the Fc to an open conformation primed for receptor binding.

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Year:  2009        PMID： 19236877     DOI： 10.1016/j.jmb.2009.02.033

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  34 in total

1.  Chemoenzymatic synthesis and Fcγ receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcγIIIa receptor.

Authors:  Guozhang Zou; Hirofumi Ochiai; Wei Huang; Qiang Yang; Cishan Li; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2011-11-01       Impact factor: 15.419

2.  Conformational Plasticity of the Immunoglobulin Fc Domain in Solution.

Authors:  Soumya G Remesh; Anthony A Armstrong; Andrew D Mahan; Jinquan Luo; Michal Hammel
Journal:  Structure       Date:  2018-05-03       Impact factor: 5.006

Review 3.  Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy.

Authors:  Ricardo J Solá; Kai Griebenow
Journal:  BioDrugs       Date:  2010-02-01       Impact factor: 5.807

4.  Influence of glycosylation pattern on the molecular properties of monoclonal antibodies.

Authors:  Kai Zheng; Mark Yarmarkovich; Christopher Bantog; Robert Bayer; Thomas W Patapoff
Journal:  MAbs       Date:  2014-03-24       Impact factor: 5.857

5.  Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions.

Authors:  Wei Huang; John Giddens; Shu-Quan Fan; Christian Toonstra; Lai-Xi Wang
Journal:  J Am Chem Soc       Date:  2012-07-16       Impact factor: 15.419

Review 6.  Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.

Authors:  David J Harvey
Journal:  Mass Spectrom Rev       Date:  2014-05-26       Impact factor: 10.946

7.  Binding structures and energies of the human neonatal Fc receptor with human Fc and its mutants by molecular modeling and dynamics simulations.

Authors:  Xiaoqin Huang; Fang Zheng; Chang-Guo Zhan
Journal:  Mol Biosyst       Date:  2013-09-20

8.  Global N-Glycan Site Occupancy of HIV-1 gp120 by Metabolic Engineering and High-Resolution Intact Mass Spectrometry.

Authors:  Weston B Struwe; Alexandra Stuckmann; Anna-Janina Behrens; Kevin Pagel; Max Crispin
Journal:  ACS Chem Biol       Date:  2017-01-09       Impact factor: 5.100

9.  Immunoglobulin G1 Fc domain motions: implications for Fc engineering.

Authors:  Martin Frank; Ross C Walker; William N Lanzilotta; James H Prestegard; Adam W Barb
Journal:  J Mol Biol       Date:  2014-02-09       Impact factor: 5.469

10.  The Structural Role of Antibody N-Glycosylation in Receptor Interactions.

Authors:  Ganesh P Subedi; Adam W Barb
Journal:  Structure       Date:  2015-07-23       Impact factor: 5.006
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