Literature DB >> 19235875

Epithelial-specific requirement of FGFR2 signaling during tooth and palate development.

Ryoichi Hosokawa1, Xuemei Deng, Kazunori Takamori, Xun Xu, Mark Urata, Pablo Bringas, Yang Chai.   

Abstract

Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial-mesenchymal tissue interaction. We have generated epithelial-specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development. K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14-Cre;Fgfr2(fl/fl) mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development. (c) 2009 Wiley-Liss, Inc.

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Year:  2009        PMID： 19235875      PMCID： PMC2896559          DOI： 10.1002/jez.b.21274

Source DB:  PubMed          Journal:  J Exp Zool B Mol Dev Evol        ISSN： 1552-5007            Impact factor:   2.656


  39 in total

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  31 in total

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8.  Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.

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Review 9.  From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.

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10.  Expression Analysis of FGF/FGFR and FOX Family Proteins in Mucosal Tissue Obtained from Orofacial Cleft-Affected Children.

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