| Literature DB >> 19232783 |
Georgia Melagraki1, Antreas Afantitis, Olga Igglessi-Markopoulou, Anastasia Detsi, Maria Koufaki, Christos Kontogiorgis, Dimitra J Hadjipavlou-Litina.
Abstract
In the present work a series of novel coumarin-3-carboxamides and their hybrids with the alpha-lipoic acid were designed, synthesized and tested as potent antioxidant and anti-inflammatory agents. The new compounds were evaluated for their antioxidant activity, their activity to inhibit in vitro lipoxygenase and their in vivo anti-inflammatory activity. In general, the derivatives were generally found to present antioxidant and anti-inflammatory activities. Discussion is made based on the results for the structure-activity relationships in order to define the structural features required for activity.Entities:
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Year: 2009 PMID： 19232783 DOI： 10.1016/j.ejmech.2008.12.027
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514