Literature DB >> 19232739

Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit.

Ilker Uçkay1, Nathalie Vernaz-Hegi, Stephan Harbarth, Richard Stern, Laurence Legout, Laetitia Vauthey, Tristan Ferry, Anne Lübbeke, Mathieu Assal, Daniel Lew, Pierre Hoffmeyer, Louis Bernard.   

Abstract

UNLABELLED: The Orthopaedic Service of the Geneva University Hospitals engages dedicated infectious disease (ID) specialists to assist in the treatment of infected patients. We investigated the daily clinical activity and the impact on antibiotic costs in the Septic Unit since 2000.
METHODS: Retrospective analysis of various databases. Prospective survey of clinical activity from January 2008 to March 2008.
RESULTS: According to the survey, the ID specialist performed 265 first-time and 1420 follow-up consultations (average of 11.4 consultations per working day). In 88% of cases the antibiotic regimen initiated by the surgeons was approved. When the ID specialist had to change antibiotic treatment, it was for de-escalation in 43.7%, discontinuance in 32.4%, and initiation in 24.4% of cases. From April 2007 to March 2008, the ID specialist decreased total antibiotic use by 43 DDD/100 patients-days (p=0.0006) in the Septic Unit. Direct antibiotic costs decreased by US$64,380 over the same period, equal to the annual salary of the ID specialist. There was no change in the number of recurrent infections.
CONCLUSIONS: The main antibiotic-related activity of the dedicated orthopaedic ID specialist in Geneva our institution was to discontinue or adjust a pre-existing antimicrobial therapy. This activity significantly reduced antibiotic use and related costs on a septic orthopaedic unit.

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Year:  2009        PMID: 19232739     DOI: 10.1016/j.jinf.2009.01.012

Source DB:  PubMed          Journal:  J Infect        ISSN: 0163-4453            Impact factor:   6.072


  18 in total

1.  Occurrence of fever in the first postoperative week does not help to diagnose infection in clean orthopaedic surgery.

Authors:  Ilker Uçkay; Americo Agostinho; Richard Stern; Louis Bernard; Pierre Hoffmeyer; Blaise Wyssa
Journal:  Int Orthop       Date:  2010-09-25       Impact factor: 3.075

2.  Evaluation of effects of an operational multidisciplinary team on antibiotic use in the medium to long term at a French university hospital.

Authors:  Béatrice Demoré; Pauline Humbert; Emmanuelle Boschetti; Sibylle Bevilacqua; Isabelle Clerc-Urmès; Thierry May; Céline Pulcini; Nathalie Thilly
Journal:  Int J Clin Pharm       Date:  2017-07-29

3.  Chronic osteomyelitis.

Authors:  Ilker Uçkay; Kheeldass Jugun; Axel Gamulin; Joe Wagener; Pierre Hoffmeyer; Daniel Lew
Journal:  Curr Infect Dis Rep       Date:  2012-10       Impact factor: 3.725

4.  Remission after treatment of osteoarticular infections due to Pseudomonas aeruginosa versus Staphylococcus aureus: a case-controlled study.

Authors:  Khalid Seghrouchni; Christian van Delden; Dennis Dominguez; Mohamed Benkabouche; Louis Bernard; Mathieu Assal; Pierre Hoffmeyer; Ilker Uçkay
Journal:  Int Orthop       Date:  2011-10-05       Impact factor: 3.075

5.  Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases.

Authors:  K de With; F Allerberger; S Amann; P Apfalter; H-R Brodt; T Eckmanns; M Fellhauer; H K Geiss; O Janata; R Krause; S Lemmen; E Meyer; H Mittermayer; U Porsche; E Presterl; S Reuter; B Sinha; R Strauß; A Wechsler-Fördös; C Wenisch; W V Kern
Journal:  Infection       Date:  2016-06       Impact factor: 3.553

6.  Noninfectious wound complications in clean surgery: epidemiology, risk factors, and association with antibiotic use.

Authors:  Ilker Uçkay; Americo Agostinho; Wilson Belaieff; Laurence Toutous-Trellu; Saja Scherer-Pietramaggiori; Axel Andres; Louis Bernard; Hubert Vuagnat; Pierre Hoffmeyer; Blaise Wyssa
Journal:  World J Surg       Date:  2011-05       Impact factor: 3.352

Review 7.  Interventions to improve antibiotic prescribing practices for hospital inpatients.

Authors:  Peter Davey; Charis A Marwick; Claire L Scott; Esmita Charani; Kirsty McNeil; Erwin Brown; Ian M Gould; Craig R Ramsay; Susan Michie
Journal:  Cochrane Database Syst Rev       Date:  2017-02-09

8.  Poor performance of microbiological sampling in the prediction of recurrent arthroplasty infection.

Authors:  Maximilian Schindler; Panayiotis Christofilopoulos; Blaise Wyssa; Wilson Belaieff; Christian Garzoni; Louis Bernard; Daniel Lew; Pierre Hoffmeyer; Ilker Uçkay
Journal:  Int Orthop       Date:  2010-04-27       Impact factor: 3.075

9.  Antimicrobial-related severe adverse events during treatment of bone and joint infection due to methicillin-susceptible Staphylococcus aureus.

Authors:  Florent Valour; Judith Karsenty; Anissa Bouaziz; Florence Ader; Michel Tod; Sébastien Lustig; Frédéric Laurent; René Ecochard; Christian Chidiac; Tristan Ferry
Journal:  Antimicrob Agents Chemother       Date:  2013-11-18       Impact factor: 5.191

10.  Epidemiology and acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in a septic orthopedic ward.

Authors:  Americo Agostinho; Gesuele Renzi; Thomas Haustein; Ghislaine Jourdan; Chantal Bonfillon; Mathieu Rougemont; Pierre Hoffmeyer; Stephan Harbarth; Ilker Uçkay
Journal:  Springerplus       Date:  2013-03-08
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