K de With1, F Allerberger2, S Amann3, P Apfalter4, H-R Brodt5, T Eckmanns6, M Fellhauer7, H K Geiss8, O Janata9, R Krause10, S Lemmen11, E Meyer12, H Mittermayer4, U Porsche13, E Presterl14, S Reuter15, B Sinha16, R Strauß17, A Wechsler-Fördös18, C Wenisch19, W V Kern20. 1. Division of Infectious Diseases, University Hospital Carl Gustav Carus at the TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany. Katja.deWith@uniklinikum-dresden.de. 2. Division Public Health, Austrian Agency for Health and Food Safety (AGES), Vienna, Austria. 3. Hospital Pharmacy, Munich Municipal Hospital, Munich, Germany. 4. Institute for Hygiene, Microbiology and Tropical Medicine (IHMT), National Reference Centre for Nosocomial Infections and Antimicrobial Resistance, Elisabethinen Hospital Linz, Linz, Austria. 5. Department of Infectious Disease Medical Clinic II, Goethe-University Frankfurt, Frankfurt, Germany. 6. Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. 7. Hospital Pharmacy, Schwarzwald-Baar Hospital, Villingen-Schwenningen, Germany. 8. Department of Hospital Epidemiology and Infectiology, Sana Kliniken AG, Ismaning, Germany. 9. Department for Hygiene and Infection Control, Danube Hospital, Vienna, Austria. 10. Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria. 11. Division of Infection Control and Infectious Diseases, University Hospital RWTH Aachen, Aachen, Germany. 12. Institute of Hygiene and Environmental Medicine, Charité, University Medicine Berlin, Berlin, Germany. 13. Department for Clinical Pharmacy and Drug Information, Landesapotheke, Landeskliniken Salzburg (SALK), Salzburg, Austria. 14. Department of Infection Control and Hospital Epidemiology, Medical University of Vienna, Vienna, Austria. 15. Clinic for General Internal Medicine, Infectious Diseases, Pneumology and Osteology, Klinikum Leverkusen, Leverkusen, Germany. 16. Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 17. Department of Medicine 1, Gastroenterology, Pneumology and Endocrinology, University Hospital Erlangen, Erlangen, Germany. 18. Department of Antibiotics and Infection Control, Krankenanstalt Rudolfstiftung, Vienna, Austria. 19. Medical Department of Infection and Tropical Medicine, Kaiser Franz Josef Hospital, Vienna, Austria. 20. Division of Infectious Diseases, Department of Medicine, Freiburg University Medical Center, Freiburg, Germany.
Abstract
INTRODUCTION: In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following societies, associations and institutions: German Society of Hospital Pharmacists, German Society for Hygiene and Microbiology, Paul Ehrlich Society for Chemotherapy, The Austrian Association of Hospital Pharmacists, Austrian Society for Infectious Diseases and Tropical Medicine, Austrian Society for Antimicrobial Chemotherapy, Robert Koch Institute. MATERIALS AND METHODS: A structured literature research was performed in the databases EMBASE, BIOSIS, MEDLINE and The Cochrane Library from January 2006 to November 2010 with an update to April 2012 (MEDLINE and The Cochrane Library). The grading of recommendations in relation to their evidence is according to the AWMF Guidance Manual and Rules for Guideline Development. CONCLUSION: The guideline provides the grounds for rational use of antibiotics in hospital to counteract antimicrobial resistance and to improve the quality of care of patients with infections by maximising clinical outcomes while minimising toxicity. Requirements for a successful implementation of ABS programmes as well as core and supplemental ABS strategies are outlined. The German version of the guideline was published by the German Association of the Scientific Medical Societies (AWMF) in December 2013.
INTRODUCTION: In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following societies, associations and institutions: German Society of Hospital Pharmacists, German Society for Hygiene and Microbiology, Paul Ehrlich Society for Chemotherapy, The Austrian Association of Hospital Pharmacists, Austrian Society for Infectious Diseases and Tropical Medicine, Austrian Society for Antimicrobial Chemotherapy, Robert Koch Institute. MATERIALS AND METHODS: A structured literature research was performed in the databases EMBASE, BIOSIS, MEDLINE and The Cochrane Library from January 2006 to November 2010 with an update to April 2012 (MEDLINE and The Cochrane Library). The grading of recommendations in relation to their evidence is according to the AWMF Guidance Manual and Rules for Guideline Development. CONCLUSION: The guideline provides the grounds for rational use of antibiotics in hospital to counteract antimicrobial resistance and to improve the quality of care of patients with infections by maximising clinical outcomes while minimising toxicity. Requirements for a successful implementation of ABS programmes as well as core and supplemental ABS strategies are outlined. The German version of the guideline was published by the German Association of the Scientific Medical Societies (AWMF) in December 2013.
Entities:
Keywords:
ABS; Antibiotic stewardship; Antimicrobial resistance; Guideline; Quality of care; Rational use
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