Literature DB >> 19231875

Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.

Reid M McCarty1, Arpád Somogyi, Vahe Bandarian.   

Abstract

To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homologue possibly involved in queuosine biosynthesis. While mammalian PTPS homologues convert 7,8-dihydroneopterin triphosphate (H(2)NTP) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin biosynthesis, E. coli QueD catalyzes the conversion of H(2)NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)). E. coli QueD can also convert PPH(4) and sepiapterin to CPH(4), allowing a mechanism to be proposed.

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Year:  2009        PMID： 19231875      PMCID： PMC3227869          DOI： 10.1021/bi9001437

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  11 in total

1.  Deciphering deazapurine biosynthesis: pathway for pyrrolopyrimidine nucleosides toyocamycin and sangivamycin.

Authors:  Reid M McCarty; Vahe Bandarian
Journal:  Chem Biol       Date:  2008-08-25

2.  The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate.

Authors:  A W Burg; G M Brown
Journal:  J Biol Chem       Date:  1968-05-10       Impact factor: 5.157

3.  From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.

Authors:  Steven G Van Lanen; John S Reader; Manal A Swairjo; Valérie de Crécy-Lagard; Bobby Lee; Dirk Iwata-Reuyl
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-14       Impact factor: 11.205

4.  Biosynthesis of the modified nucleoside Q in transfer RNA.

Authors:  Y Kuchino; H Kasai; K Nihei; S Nishimura
Journal:  Nucleic Acids Res       Date:  1976-02       Impact factor: 16.971

Review 5.  The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase.

Authors:  G Auerbach; H Nar
Journal:  Biol Chem       Date:  1997 Mar-Apr       Impact factor: 3.915

6.  Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.

Authors:  H J Sofia; G Chen; B G Hetzler; J F Reyes-Spindola; N E Miller
Journal:  Nucleic Acids Res       Date:  2001-03-01       Impact factor: 16.971

7.  Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli.

Authors:  Rahul Gaur; Umesh Varshney
Journal:  J Bacteriol       Date:  2005-10       Impact factor: 3.490

8.  Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin.

Authors:  Hyun Joo Woo; Yoon Kyung Hwang; Yeon Jung Kim; Jee Yun Kang; Yong Kee Choi; Chun Gyu Kim; Young Shik Park
Journal:  FEBS Lett       Date:  2002-07-17       Impact factor: 4.124

9.  Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.

Authors:  John S Reader; David Metzgar; Paul Schimmel; Valérie de Crécy-Lagard
Journal:  J Biol Chem       Date:  2003-12-02       Impact factor: 5.157

10.  6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding.

Authors:  D M Bürgisser; B Thöny; U Redweik; D Hess; C W Heizmann; R Huber; H Nar
Journal:  J Mol Biol       Date:  1995-10-20       Impact factor: 5.469
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  24 in total

Review 1.  Radical SAM enzymes involved in the biosynthesis of purine-based natural products.

Authors:  Vahe Bandarian
Journal:  Biochim Biophys Acta       Date:  2012-08-03

Review 2.  Biosynthesis of pyrrolopyrimidines.

Authors:  Reid M McCarty; Vahe Bandarian
Journal:  Bioorg Chem       Date:  2012-01-31       Impact factor: 5.275

Review 3.  Radical S-adenosylmethionine enzymes.

Authors:  Joan B Broderick; Benjamin R Duffus; Kaitlin S Duschene; Eric M Shepard
Journal:  Chem Rev       Date:  2014-01-29       Impact factor: 60.622

4.  Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification.

Authors:  Zachary D Miles; Reid M McCarty; Gabriella Molnar; Vahe Bandarian
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-18       Impact factor: 11.205

5.  Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily.

Authors:  Zachary D Miles; Sue A Roberts; Reid M McCarty; Vahe Bandarian
Journal:  J Biol Chem       Date:  2014-07-02       Impact factor: 5.157

6.  The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.

Authors:  Reid M McCarty; Arpád Somogyi; Guangxin Lin; Neil E Jacobsen; Vahe Bandarian
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

7.  6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria.

Authors:  Anne Pribat; Linda Jeanguenin; Aurora Lara-Núñez; Michael J Ziemak; John E Hyde; Valérie de Crécy-Lagard; Andrew D Hanson
Journal:  J Bacteriol       Date:  2009-04-24       Impact factor: 3.490

Review 8.  Radical-mediated ring contraction in the biosynthesis of 7-deazapurines.

Authors:  Vahe Bandarian; Catherine L Drennan
Journal:  Curr Opin Struct Biol       Date:  2015-11-28       Impact factor: 6.809

9.  Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine.

Authors:  Zachary D Miles; William K Myers; William M Kincannon; R David Britt; Vahe Bandarian
Journal:  Biochemistry       Date:  2015-07-31       Impact factor: 3.162

10.  Archaeosine Modification of Archaeal tRNA: Role in Structural Stabilization.

Authors:  Ben Turner; Brett W Burkhart; Katrin Weidenbach; Robert Ross; Patrick A Limbach; Ruth A Schmitz; Valérie de Crécy-Lagard; Kenneth M Stedman; Thomas J Santangelo; Dirk Iwata-Reuyl
Journal:  J Bacteriol       Date:  2020-03-26       Impact factor: 3.490
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