Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Efficient and regioselective halogenations of 2-amino-1,3-thiazoles with copper salts.

Literature DB >> 19231816

Efficient and regioselective halogenations of 2-amino-1,3-thiazoles with copper salts.

Fabrice G Siméon¹, Matthew T Wendahl, Victor W Pike.

Abstract

Monohalo and dihalo 1,3-thiazole derivatives can be efficiently and selectively prepared under mild conditions from 2-amino-1,3-thiazoles. Halogenations proceed easily in the presence of copper(I) or copper(II) chlorides, bromides, or iodides directly in solution or with supported copper halides.

Entities: Chemical Disease Gene

Mesh：

Substances：
Salts
Thiazoles
Copper

Year: 2009 PMID： 19231816 PMCID： PMC2796164 DOI： 10.1021/jo802799c

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

9 in total

1. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Authors: Nicholas D P Cosford; Lida Tehrani; Jeffrey Roppe; Edwin Schweiger; Nicholas D Smith; Jeffrey Anderson; Linda Bristow; Jesse Brodkin; Xiaohui Jiang; Ian McDonald; Sara Rao; Mark Washburn; Mark A Varney
Journal: J Med Chem Date: 2003-01-16 Impact factor: 7.446

2. Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.

Authors: Fabrice G Siméon; Amira K Brown; Sami S Zoghbi; Velvet M Patterson; Robert B Innis; Victor W Pike
Journal: J Med Chem Date: 2007-06-16 Impact factor: 7.446

3. Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain.

Authors: H Umesha Shetty; Sami S Zoghbi; Fabrice G Siméon; Jeih-San Liow; Amira K Brown; Pavitra Kannan; Robert B Innis; Victor W Pike
Journal: J Pharmacol Exp Ther Date: 2008-09-19 Impact factor: 4.030

4. Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers.

Authors: Terence G Hamill; Stephen Krause; Christine Ryan; Celine Bonnefous; Steve Govek; T Jon Seiders; Nicholas D P Cosford; Jeffrey Roppe; Ted Kamenecka; Shil Patel; Raymond E Gibson; Sandra Sanabria; Kerry Riffel; Waisi Eng; Christopher King; Xiaoqing Yang; Mitchell D Green; Stacey S O'Malley; Richard Hargreaves; H Donald Burns
Journal: Synapse Date: 2005-06-15 Impact factor: 2.562

5. Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.

Authors: K C Nicolaou; N P King; M R Finlay; Y He; F Roschangar; D Vourloumis; H Vallberg; F Sarabia; S Ninkovic; D Hepworth
Journal: Bioorg Med Chem Date: 1999-05 Impact factor: 3.641

6. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.

Authors: Yasuyoshi Iso; Ewa Grajkowska; Jarda T Wroblewski; Jared Davis; Nicholas E Goeders; Kenneth M Johnson; Subramaniam Sanker; Bryan L Roth; Werner Tueckmantel; Alan P Kozikowski
Journal: J Med Chem Date: 2006-02-09 Impact factor: 7.446

7. Halogenated 2'-chlorobithiazoles via Pd-catalyzed cross-coupling reactions.

Authors: Peter Stanetty; Michael Schnürch; Marko D Mihovilovic
Journal: J Org Chem Date: 2006-05-12 Impact factor: 4.354

8. Rapid and mild syntheses of radioiodine-labeled radiopharmaceuticals.

Authors: G W Kabalka; E E Gooch; K A Sastry
Journal: J Nucl Med Date: 1981-10 Impact factor: 10.057

9. Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET.

Authors: Amira K Brown; Yasuyuki Kimura; Sami S Zoghbi; Fabrice G Siméon; Jeih-San Liow; William C Kreisl; Andrew Taku; Masahiro Fujita; Victor W Pike; Robert B Innis
Journal: J Nucl Med Date: 2008-12 Impact factor: 10.057

9 in total

5 in total

1. The [F]2-Fluoro-1,3-thiazolyl Moiety - an Easily-Accessible Structural Motif for Prospective Molecular Imaging Radiotracers.

Authors: Fabrice G Siméon; Matthew T Wendahl; Victor W Pike
Journal: Tetrahedron Lett Date: 2010-11-17 Impact factor: 2.415

2. Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.

Authors: Fabrice G Siméon; Matthew T Wendahl; Victor W Pike
Journal: J Med Chem Date: 2011-01-05 Impact factor: 7.446