Literature DB >> 19231595

DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.

Jason A Hackney1, Shahram Misaghi, Kate Senger, Christopher Garris, Yonglian Sun, Maria N Lorenzo, Ali A Zarrin.   

Abstract

As part of the adaptive immune response, B cells alter their functional immunoglobulin (Ig) receptor genes through somatic hypermutation (SHM) and/or class switch recombination (CSR) via processes that are initiated by activation induced cytidine deaminase (AID). These genetic modifications are targeted at specific sequences known as Variable (V) and Switch (S) regions. Here, we analyze and review the properties and function of AID target sequences across species and compare them with non-Ig sequences, including known translocation hotspots. We describe properties of the S sequences, and discuss species and isotypic differences among S regions. Common properties of SHM and CSR target sequences suggest that evolution of S regions might involve the duplication and selection of SHM hotspots.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19231595     DOI： 10.1016/S0065-2776(08)01005-5

Source DB:  PubMed          Journal:  Adv Immunol        ISSN： 0065-2776            Impact factor:   3.543


  34 in total

1.  Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.

Authors:  Rahul M Kohli; Robert W Maul; Amy F Guminski; Rhonda L McClure; Kiran S Gajula; Huseyin Saribasak; Moira A McMahon; Robert F Siliciano; Patricia J Gearhart; James T Stivers
Journal:  J Biol Chem       Date:  2010-10-06       Impact factor: 5.157

Review 2.  Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.

Authors:  Zhenming Xu; Hong Zan; Egest J Pone; Thach Mai; Paolo Casali
Journal:  Nat Rev Immunol       Date:  2012-06-25       Impact factor: 53.106

3.  The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombination.

Authors:  Zheng Z Zhang; Nicholas R Pannunzio; Zhengfei Lu; Ellen Hsu; Kefei Yu; Michael R Lieber
Journal:  Mol Immunol       Date:  2015-08-12       Impact factor: 4.407

4.  Transcription factor YY1 can control AID-mediated mutagenesis in mice.

Authors:  Kristina Zaprazna; Arindam Basu; Nikola Tom; Vibha Jha; Suchita Hodawadekar; Lenka Radova; Jitka Malcikova; Boris Tichy; Sarka Pospisilova; Michael L Atchison
Journal:  Eur J Immunol       Date:  2017-11-14       Impact factor: 5.532

5.  Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

Authors:  Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; Wei Yu Lin; Zhonghua Lin; Maria N Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary D Austin; Mercedesz Balazs; Merone Roose-Girma; Laura DeForge; Søren Warming; Wyne P Lee; Vishva M Dixit; Ali A Zarrin
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

6.  Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.

Authors:  Li Han; Shahnaz Masani; Kefei Yu
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-27       Impact factor: 11.205

7.  Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.

Authors:  Amélie Bonaud; Fabien Lechouane; Sandrine Le Noir; Olivier Monestier; Michel Cogné; Christophe Sirac
Journal:  Nat Commun       Date:  2015-07-06       Impact factor: 14.919

Review 8.  Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.

Authors:  Joyce K Hwang; Frederick W Alt; Leng-Siew Yeap
Journal:  Microbiol Spectr       Date:  2015-02

Review 9.  Mechanisms of chromosomal rearrangement in the human genome.

Authors:  Albert G Tsai; Michael R Lieber
Journal:  BMC Genomics       Date:  2010-02-10       Impact factor: 3.969

Review 10.  Generation and repair of AID-initiated DNA lesions in B lymphocytes.

Authors:  Zhangguo Chen; Jing H Wang
Journal:  Front Med       Date:  2014-04-21       Impact factor: 4.592
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.