Literature DB >> 19231219

Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and the role of ethanol and radioactive concentration.

Mark S Jacobson1, Heather R Dankwart, Douglas W Mahoney.   

Abstract

Radiolysis is the process by which radioactively labeled compounds degrade. Many positron emission tomography (PET) radiopharmaceuticals produced with high radioactive concentrations and specific activities exhibit low radiochemical purity because of radiolysis. Little data exist that describe the radiolytic decomposition of 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG). The objective of our study was to profile the degradation of [(18)F]FDG at various radioactive concentrations by measuring radiochemical purity at different time intervals and to study the effects of ethanol, a well-known reductant stabilizer of [(18)F]FDG preparations.

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Year:  2009        PMID： 19231219     DOI： 10.1016/j.apradiso.2009.01.005

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  8 in total

Review 1.  Microfluidics for positron emission tomography probe development.

Authors:  Ming-Wei Wang; Wei-Yu Lin; Kan Liu; Michael Masterman-Smith; Clifton Kwang-Fu Shen
Journal:  Mol Imaging       Date:  2010-08       Impact factor: 4.488

2.  Radiosynthesis of [124I]iodometomidate and biological evaluation using small-animal PET.

Authors:  Herbert Kvaternik; Thomas Wanek; Friedrich Hammerschmidt; Ilse Zolle; Reingard Aigner; Claudia Kuntner
Journal:  Mol Imaging Biol       Date:  2014-06       Impact factor: 3.488

3.  High-yielding aqueous 18F-labeling of peptides via Al18F chelation.

Authors:  Christopher A D'Souza; William J McBride; Robert M Sharkey; Louis J Todaro; David M Goldenberg
Journal:  Bioconjug Chem       Date:  2011-08-09       Impact factor: 4.774

4.  Optimization of precursor synthesis, formulation and stability of 1'-[18F]fluoroethyl-β-D-lactose ([18F]FEL) for preclinical studies in detection of pancreatic cancer.

Authors:  Vincenzo Paolillo; Louis De Palatis; Mian M Alauddin
Journal:  Nucl Med Biol       Date:  2014-01-10       Impact factor: 2.408

5.  Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.

Authors:  Tobey J Betthauser; Paul A Ellison; Dhanabalan Murali; Patrick J Lao; Todd E Barnhart; Shozo Furumoto; Nobuyuki Okamura; Sterling C Johnson; Jonathan W Engle; Robert J Nickles; Bradley T Christian
Journal:  Appl Radiat Isot       Date:  2017-10-04       Impact factor: 1.513

6.  Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

Authors:  Jeffrey S Stehouwer; Matthew S Birnbaum; Ronald J Voll; Michael J Owens; Susan J Plott; Chase H Bourke; Michael A Wassef; Clinton D Kilts; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2015-06-19       Impact factor: 3.641

7.  Comparison of the Intraperitoneal, Retroorbital and per Oral Routes for F-18 FDG Administration as Effective Alternatives to Intravenous Administration in Mouse Tumor Models Using Small Animal PET/CT Studies.

Authors:  Chulhan Kim; In Hye Kim; Seo-Il Kim; Young Sang Kim; Se Hun Kang; Seung Hwan Moon; Tae-Sung Kim; Seok-Ki Kim
Journal:  Nucl Med Mol Imaging       Date:  2011-05-27

8.  Stability evaluation of [18F]FDG: literature study, stability studies from two different PET centres and future recommendations.

Authors:  Jes G Holler; Børge Renmælmo; Richard Fjellaksel
Journal:  EJNMMI Radiopharm Chem       Date:  2022-02-24
  8 in total

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