Literature DB >> 19228040

Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600.

Sheng-Xiong Huang1, Li-Xing Zhao, Shu-Kun Tang, Cheng-Lin Jiang, Yanwen Duan, Ben Shen.   

Abstract

Erythronolides H and I, novel congeners of the clinically important antibacterial drug erythromycin A, have been isolated from the new halophilic actinomycete Actinopolyspora sp. YIM90600. In addition to producing the new erythromycin congeners, A. sp. YIM90600 produces erythromycin C in a high titer. The presence of the C-14 hydroxyl moiety and the C-6/C-18-epoxide in erythronolide H and the spiroketal moiety of erythronolide I sheds new insights into structural diversity of erythromycin analog libraries potentially accessible by combinatorial biosynthesis.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19228040      PMCID： PMC4123550          DOI： 10.1021/ol900143j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  20 in total

1.  Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.

Authors:  Y S Or; R F Clark; S Wang; D T Chu; A M Nilius; R K Flamm; M Mitten; P Ewing; J Alder; Z Ma
Journal:  J Med Chem       Date:  2000-03-23       Impact factor: 7.446

Review 2.  Translation and protein synthesis: macrolides.

Authors:  Leonard Katz; Gary W Ashley
Journal:  Chem Rev       Date:  2005-02       Impact factor: 60.622

3.  Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic.

Authors:  Stefanie Heller; Laurenz Kellenberger; Stuart Shapiro
Journal:  Antimicrob Agents Chemother       Date:  2007-03-26       Impact factor: 5.191

4.  New ether oxime derivatives of erythromycin A. A structure-activity relationship study.

Authors:  J C Gasc; S G d'Ambrieres; A Lutz; J F Chantot
Journal:  J Antibiot (Tokyo)       Date:  1991-03       Impact factor: 2.649

5.  Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea.

Authors:  Sabine Gaisser; Rachel Lill; James Staunton; Carmen Méndez; José Salas; Peter F Leadlay
Journal:  Mol Microbiol       Date:  2002-05       Impact factor: 3.501

6.  Isolation and characterization of Actinopolyspora halophila, gen. et sp. nov., an extremely halophilic actinomycete.

Authors:  M B Gochnauer; G G Leppard; P Komaratat; M Kates; T Novitsky; D J Kushner
Journal:  Can J Microbiol       Date:  1975-10       Impact factor: 2.419

7.  Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-AZA-9a-homoerythromycin A derivatives; a new class of macrolide antibiotics, the azalides.

Authors:  G M Bright; A A Nagel; J Bordner; K A Desai; J N Dibrino; J Nowakowska; L Vincent; R M Watrous; F C Sciavolino; A R English
Journal:  J Antibiot (Tokyo)       Date:  1988-08       Impact factor: 2.649

8.  Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.

Authors:  R H Lambalot; D E Cane; J J Aparicio; L Katz
Journal:  Biochemistry       Date:  1995-02-14       Impact factor: 3.162

Review 9.  Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections.

Authors:  Margaret R Hammerschlag; Roopali Sharma
Journal:  Expert Opin Investig Drugs       Date:  2008-03       Impact factor: 6.206

10.  Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation.

Authors:  Guoqiang Wang; Deqiang Niu; Yao-Ling Qiu; Ly Tam Phan; Zhigang Chen; Alexander Polemeropoulos; Yat Sun Or
Journal:  Org Lett       Date:  2004-11-25       Impact factor: 6.005
View more
  9 in total

1.  New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.

Authors:  Zhikai Guo; Guohui Pan; Zhengren Xu; Dong Yang; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2016-10-12       Impact factor: 2.649

2.  Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis.

Authors:  Sang-Jip Nam; Susana P Gaudêncio; Christopher A Kauffman; Paul R Jensen; Tamara P Kondratyuk; Laura E Marler; John M Pezzuto; William Fenical
Journal:  J Nat Prod       Date:  2010-06-25       Impact factor: 4.050

3.  Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.

Authors:  Li-Xing Zhao; Sheng-Xiong Huang; Shu-Kun Tang; Cheng-Lin Jiang; Yanwen Duan; John A Beutler; Curtis J Henrich; James B McMahon; Tobias Schmid; Johanna S Blees; Nancy H Colburn; Scott R Rajski; Ben Shen
Journal:  J Nat Prod       Date:  2011-08-26       Impact factor: 4.050

4.  Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211.

Authors:  Sheng-Xiong Huang; Xiang-Jing Wang; Yijun Yan; Ji-Dong Wang; Ji Zhang; Chong-Xi Liu; Wen-Sheng Xiang; Ben Shen
Journal:  Org Lett       Date:  2012-02-14       Impact factor: 6.005

5.  Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209.

Authors:  Zhiguo Yu; Li-Xing Zhao; Cheng-Lin Jiang; Yanwen Duan; Lily Wong; Kristopher C Carver; Linda A Schuler; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2010-11-24       Impact factor: 2.649

6.  Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action.

Authors:  Brad Tebbets; Zhiguo Yu; Douglas Stewart; Li-Xing Zhao; Yi Jiang; Li-Hua Xu; David Andes; Ben Shen; Bruce Klein
Journal:  Med Mycol       Date:  2012-08-28       Impact factor: 4.076

7.  Systematic and biotechnological aspects of halophilic and halotolerant actinomycetes.

Authors:  Javad Hamedi; Fatemeh Mohammadipanah; Antonio Ventosa
Journal:  Extremophiles       Date:  2012-11-06       Impact factor: 2.395

8.  Structure and conformational analysis of spiroketals from 6-O-methyl-9(E)-hydroxyiminoerythronolide A.

Authors:  Ana Čikoš; Irena Ćaleta; Dinko Žiher; Mark B Vine; Ivaylo J Elenkov; Marko Dukši; Dubravka Gembarovski; Marina Ilijaš; Snježana Dragojević; Ivica Malnar; Sulejman Alihodžić
Journal:  Beilstein J Org Chem       Date:  2015-08-19       Impact factor: 2.883

9.  Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field.

Authors:  Dandan Chen; Junyin Feng; Lei Huang; Qinglin Zhang; Jiequn Wu; Xiangcheng Zhu; Yanwen Duan; Zhinan Xu
Journal:  PLoS One       Date:  2014-09-24       Impact factor: 3.240
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.