OBJECTIVE: Capitalizing on phenomena at the nanoscale may present great benefits to society. Nevertheless, until the hazards and risks of engineered nanoparticles are determined, the technological products and advances of nanotechnology may be impeded by the societal concerns. Although animal data provide the necessary first step in hazard and risk assessment, ultimately epidemiological studies will be required, especially studies of workers exposed to engineered nanoparticles. It may be too soon to conduct informative epidemiological studies but it is now appropriate to identify issues that will be pertinent and prepare strategies to address them. METHODS: The published scientific literature on incidental and engineered nanoparticles and air pollution were reviewed to identify issues in the conduct of epidemiological studies of workers exposed to engineered nanoparticles. RESULTS: Twelve important issues were identified-the most critical pertaining to particle heterogeneity, temporal factors, exposure characterization, disease endpoints, and identification of the study population. CONCLUSION: Consideration of these issues provides the foundation for initiating epidemiologic research on workers exposed to engineered nanoparticles.
OBJECTIVE: Capitalizing on phenomena at the nanoscale may present great benefits to society. Nevertheless, until the hazards and risks of engineered nanoparticles are determined, the technological products and advances of nanotechnology may be impeded by the societal concerns. Although animal data provide the necessary first step in hazard and risk assessment, ultimately epidemiological studies will be required, especially studies of workers exposed to engineered nanoparticles. It may be too soon to conduct informative epidemiological studies but it is now appropriate to identify issues that will be pertinent and prepare strategies to address them. METHODS: The published scientific literature on incidental and engineered nanoparticles and air pollution were reviewed to identify issues in the conduct of epidemiological studies of workers exposed to engineered nanoparticles. RESULTS: Twelve important issues were identified-the most critical pertaining to particle heterogeneity, temporal factors, exposure characterization, disease endpoints, and identification of the study population. CONCLUSION: Consideration of these issues provides the foundation for initiating epidemiologic research on workers exposed to engineered nanoparticles.
Authors: Larissa V Stebounova; Natalia I Gonzalez-Pech; Jae Hong Park; T Renee Anthony; Vicki H Grassian; Thomas M Peters Journal: Ann Work Expo Health Date: 2018-07-06 Impact factor: 2.179
Authors: Irina Guseva Canu; Paul A Schulte; Michael Riediker; Liliya Fatkhutdinova; Enrico Bergamaschi Journal: J Epidemiol Community Health Date: 2017-12-04 Impact factor: 3.710
Authors: P A Schulte; G Roth; L L Hodson; V Murashov; M D Hoover; R Zumwalde; E D Kuempel; C L Geraci; A B Stefaniak; V Castranova; J Howard Journal: J Nanopart Res Date: 2016-06-14 Impact factor: 2.253
Authors: Elizabeth M Ward; Paul A Schulte; Kurt Straif; Nancy B Hopf; Jane C Caldwell; Tania Carreón; David M DeMarini; Bruce A Fowler; Bernard D Goldstein; Kari Hemminki; Cynthia J Hines; Kirsti Husgafvel Pursiainen; Eileen Kuempel; Joellen Lewtas; Ruth M Lunn; Elsebeth Lynge; Damien M McElvenny; Hartwig Muhle; Tamie Nakajima; Larry W Robertson; Nathaniel Rothman; Avima M Ruder; Mary K Schubauer-Berigan; Jack Siemiatycki; Debra Silverman; Martyn T Smith; Tom Sorahan; Kyle Steenland; Richard G Stevens; Paolo Vineis; Shelia Hoar Zahm; Lauren Zeise; Vincent J Cogliano Journal: Environ Health Perspect Date: 2010-06-18 Impact factor: 9.031
Authors: Saou-Hsing Liou; Candace S J Tsai; Daniela Pelclova; Mary K Schubauer-Berigan; Paul A Schulte Journal: J Nanopart Res Date: 2015-10-19 Impact factor: 2.253