Literature DB >> 12760872

Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits.

Javier Capilla1, Clara Yustes, Emili Mayayo, Belkys Fernández, Montserrat Ortoneda, F Javier Pastor, Josep Guarro.   

Abstract

There are no effective therapeutics for treating invasive Scedosporium prolificans infections. Doses of 15, 25, and 50 mg/kg of body weight/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg/kg/day at clearing S. prolificans from tissue (P < 0.007). The percentages of survival at 25 mg of ABC/kg/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (P < 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.

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Year:  2003        PMID： 12760872      PMCID： PMC155847          DOI： 10.1128/AAC.47.6.1948-1951.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

Review 1.  Deep infections caused by Scedosporium prolificans. A report on 16 cases in Spain and a review of the literature. Scedosporium Prolificans Spanish Study Group.

Authors:  J Berenguer; J L Rodríguez-Tudela; C Richard; M Alvarez; M A Sanz; L Gaztelurrutia; J Ayats; J V Martinez-Suarez
Journal:  Medicine (Baltimore)       Date:  1997-07       Impact factor: 1.889

2.  New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones.

Authors:  J Bartroli; E Turmo; M Algueró; E Boncompte; M L Vericat; L Conte; J Ramis; M Merlos; J García-Rafanell; J Forn
Journal:  J Med Chem       Date:  1998-05-21       Impact factor: 7.446

3.  Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum.

Authors:  M Cuenca-Estrella; B Ruiz-Díez; J V Martínez-Suárez; A Monzón; J L Rodríguez-Tudela
Journal:  J Antimicrob Chemother       Date:  1999-01       Impact factor: 5.790

4.  Liposomal amphotericin B and granulocyte colony-stimulating factor therapy in a murine model of invasive infection by Scedosporium prolificans.

Authors:  Montserrat Ortoneda; Javier Capilla; Isabel Pujol; F Javier Pastor; Emilio Mayayo; Joan Fernández-Ballart; Josep Guarro
Journal:  J Antimicrob Chemother       Date:  2002-03       Impact factor: 5.790

5.  In-vitro comparative activity of UR-9825, itraconazole and fluconazole against clinical isolates of Candida spp.

Authors:  G Ramos; M Cuenca-Estrella; A Monzón; J L Rodríguez-Tudela
Journal:  J Antimicrob Chemother       Date:  1999-08       Impact factor: 5.790

6.  A model of coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit.

Authors:  P L Williams; R A Sobel; K N Sorensen; K V Clemons; L M Shuer; S S Royaltey; Y Yao; D Pappagianis; J E Lutz; C Reed; M E River; B C Lee; S U Bhatti; D A Stevens
Journal:  J Infect Dis       Date:  1998-10       Impact factor: 5.226

7.  Clinical features of human infection with Scedosporium inflatum.

Authors:  G M Wood; J G McCormack; D B Muir; D H Ellis; M F Ridley; R Pritchard; M Harrison
Journal:  Clin Infect Dis       Date:  1992-05       Impact factor: 9.079

8.  Experimental infection with Scedosporium inflatum.

Authors:  J Cano; J Guarro; E Mayayo; J Fernandez-Ballart
Journal:  J Med Vet Mycol       Date:  1992

9.  Ecology and physiology of the emerging opportunistic fungi Pseudallescheria boydii and Scedosporium prolificans.

Authors:  G S de Hoog; F D Marvin-Sikkema; G A Lahpoor; J C Gottschall; R A Prins; E Guého
Journal:  Mycoses       Date:  1994 Mar-Apr       Impact factor: 4.377

10.  Development of a murine model of cerebral aspergillosis.

Authors:  Tom M Chiller; Javier Capilla Luque; Raymond A Sobel; Kouros Farrokhshad; Karl V Clemons; David A Stevens
Journal:  J Infect Dis       Date:  2002-08-02       Impact factor: 5.226
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  9 in total

1.  Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding.

Authors:  Chunquan Sheng; Zhenyuan Miao; Haitao Ji; Jianzhong Yao; Wenya Wang; Xiaoying Che; Guoqiang Dong; Jiaguo Lü; Wei Guo; Wannian Zhang
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

2.  In vitro synergistic interaction between amphotericin B and micafungin against Scedosporium spp.

Authors:  Clara Yustes; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

3.  Comparative Pathogenicity of Lomentospora prolificans (Scedosporium prolificans) Isolates from Mexican Patients.

Authors:  Mariana Elizondo-Zertuche; Alexandra M Montoya; Efrén Robledo-Leal; Idalia Garza-Veloz; Ana L Sánchez-Núñez; Raquel Ballesteros-Elizondo; Gloria M González
Journal:  Mycopathologia       Date:  2017-04-29       Impact factor: 2.574

Review 4.  Infections caused by Scedosporium spp.

Authors:  Karoll J Cortez; Emmanuel Roilides; Flavio Quiroz-Telles; Joseph Meletiadis; Charalampos Antachopoulos; Tena Knudsen; Wendy Buchanan; Jeffrey Milanovich; Deanna A Sutton; Annette Fothergill; Michael G Rinaldi; Yvonne R Shea; Theoklis Zaoutis; Shyam Kottilil; Thomas J Walsh
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

5.  Design, synthesis, and biological activities of novel azole-bonded β-hydroxypropyl oxime O-ethers.

Authors:  Somayeh Behrouz; Mohammad Navid Soltani Rad; Saeid Rostami; Marzieh Behrouz; Elham Zarehnezhad; Ali Zarehnezhad
Journal:  Mol Divers       Date:  2014-08-01       Impact factor: 2.943

6.  Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.

Authors:  M Mar Rodríguez; Enrique Calvo; Carolina Serena; Marçal Mariné; F Javier Pastor; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2009-02-17       Impact factor: 5.191

7.  Secretion of Proteases by an Opportunistic Fungal Pathogen Scedosporium aurantiacum.

Authors:  Zhiping Han; Liisa Kautto; Helena Nevalainen
Journal:  PLoS One       Date:  2017-01-06       Impact factor: 3.240

8.  In Vivo Efficacy of Olorofim against Systemic Scedosporiosis and Lomentosporiosis.

Authors:  S Seyedmousavi; Y C Chang; J H Youn; D Law; M Birch; J H Rex; K J Kwon-Chung
Journal:  Antimicrob Agents Chemother       Date:  2021-07-12       Impact factor: 5.191

Review 9.  Animal models: an important tool in mycology.

Authors:  Javier Capilla; Karl V Clemons; David A Stevens
Journal:  Med Mycol       Date:  2007-12       Impact factor: 4.076
  9 in total

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