Literature DB >> 19222788

Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni.

G Ahmad1, W Torben, W Zhang, M Wyatt, A A Siddiqui.   

Abstract

No effective vaccine exists for the human parasitic disease, schistosomiasis. We have targeted a functionally important antigen, Sm-p80 as a vaccine candidate because of its consistent immunogenicity, protective potential and important role in the immune evasion process. In this study we report that a Sm-p80-based DNA vaccine formulation confers 59% reduction in worm burden in mice. Animals immunized with Sm-p80-pcDNA3 exhibited a decrease in egg production by 84%. Sm-p80 DNA elicited strong immune responses that include IgG2A and IgG2B antibody isotypes in vaccinated animals. Splenocytes proliferated in response to Sm-p80 produced appreciably more Th1 response enhancing cytokines (IL-2, IFN-gamma) than Th2 response enhancing cytokines (IL-4, IL-10). These data reinforce the potential of Sm-p80 as an excellent vaccine candidate for schistosomiasis.

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Year:  2009        PMID： 19222788      PMCID： PMC2786212          DOI： 10.1111/j.1365-3024.2008.01091.x

Source DB:  PubMed          Journal:  Parasite Immunol        ISSN： 0141-9838            Impact factor:   2.280


  37 in total

1.  Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

Authors:  R A Montgomery; M J Dallman
Journal:  J Immunol       Date:  1991-07-15       Impact factor: 5.422

2.  Molecular cloning and sequence analysis of a calcium-activated neutral protease (calpain) from Schistosoma mansoni.

Authors:  S R Karcz; R B Podesta; A A Siddiqui; G A Dekaban; G H Strejan; M W Clarke
Journal:  Mol Biochem Parasitol       Date:  1991-12       Impact factor: 1.759

3.  Pro-IL-16 regulation in activated murine CD4+ lymphocytes.

Authors:  Fucheng Ren; Xin Zhan; Gregory Martens; Jinhee Lee; David Center; Sue Kim Hanson; Hardy Kornfeld
Journal:  J Immunol       Date:  2005-03-01       Impact factor: 5.422

4.  Complement and 5-HT increase phosphatidylcholine incorporation into the outer bilayers of Schistosoma mansoni.

Authors:  B W Young; R B Podesta
Journal:  J Parasitol       Date:  1986-10       Impact factor: 1.276

5.  Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18.

Authors:  B R Lauwerys; N Garot; J C Renauld; F A Houssiau
Journal:  J Immunol       Date:  2000-08-15       Impact factor: 5.422

6.  Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon.

Authors:  Afzal A Siddiqui; Justin R Pinkston; Martha L Quinlin; Qaiser Saeed; Gary L White; Michael H Shearer; Ronald C Kennedy
Journal:  Vaccine       Date:  2005-02-10       Impact factor: 3.641

7.  Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation.

Authors:  Afzal A Siddiqui; Troy Phillips; Hugues Charest; Ron B Podesta; Martha L Quinlin; Justin R Pinkston; Jenny D Lloyd; Janet Pompa; Rachael M Villalovos; Michelle Paz
Journal:  Vaccine       Date:  2003-06-20       Impact factor: 3.641

8.  Interleukin-21 inhibits dendritic cell activation and maturation.

Authors:  Katja Brandt; Silvia Bulfone-Paus; Donald C Foster; René Rückert
Journal:  Blood       Date:  2003-07-31       Impact factor: 22.113

Review 9.  Current status and future prospects for a vaccine against schistosomiasis.

Authors:  Michael Lebens; Jia-Bin Sun; Cecil Czerkinsky; Jan Holmgren
Journal:  Expert Rev Vaccines       Date:  2004-06       Impact factor: 5.217

Review 10.  IL-1, IL-18, and IL-33 families of cytokines.

Authors:  William P Arend; Gaby Palmer; Cem Gabay
Journal:  Immunol Rev       Date:  2008-06       Impact factor: 12.988
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  28 in total

1.  Role of antibodies in Sm-p80-mediated protection against Schistosoma mansoni challenge infection in murine and nonhuman primate models.

Authors:  Workineh Torben; Gul Ahmad; Weidong Zhang; Afzal A Siddiqui
Journal:  Vaccine       Date:  2011-01-28       Impact factor: 3.641

2.  Preclinical prophylactic efficacy testing of Sm-p80-based vaccine in a nonhuman primate model of Schistosoma mansoni infection and immunoglobulin G and E responses to Sm-p80 in human serum samples from an area where schistosomiasis is endemic.

Authors:  Gul Ahmad; Weidong Zhang; Workineh Torben; Afzal Ahrorov; Raymond T Damian; Roman F Wolf; Gary L White; David W Carey; Pauline N M Mwinzi; Lisa Ganley-Leal; Ronald C Kennedy; Afzal A Siddiqui
Journal:  J Infect Dis       Date:  2011-09-15       Impact factor: 5.226

3.  Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons.

Authors:  Souvik Karmakar; Weidong Zhang; Gul Ahmad; Workineh Torben; Mayeen U Alam; Loc Le; Raymond T Damian; Roman F Wolf; Gary L White; David W Carey; Darrick Carter; Steven G Reed; Afzal A Siddiqui
Journal:  Vaccine       Date:  2014-01-04       Impact factor: 3.641

4.  Sm-p80-based DNA vaccine provides baboons with levels of protection against Schistosoma mansoni infection comparable to those achieved by the irradiated cercarial vaccine.

Authors:  Weidong Zhang; Gul Ahmad; Workineh Torben; Zahid Noor; Loc Le; Raymond T Damian; Roman F Wolf; Gary L White; Maria Chavez-Suarez; Ronald B Podesta; Ronald C Kennedy; Afzal A Siddiqui
Journal:  J Infect Dis       Date:  2010-04-01       Impact factor: 5.226

Review 5.  Vaccines to combat the neglected tropical diseases.

Authors:  Jeffrey M Bethony; Rhea N Cole; Xiaoti Guo; Shaden Kamhawi; Marshall W Lightowlers; Alex Loukas; William Petri; Steven Reed; Jesus G Valenzuela; Peter J Hotez
Journal:  Immunol Rev       Date:  2011-01       Impact factor: 12.988

Review 6.  Schistosomiasis vaccines.

Authors:  Afzal A Siddiqui; Bilal A Siddiqui; Lisa Ganley-Leal
Journal:  Hum Vaccin       Date:  2011-11-01

7.  Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons.

Authors:  Souvik Karmakar; Weidong Zhang; Gul Ahmad; Workineh Torben; Mayeen U Alam; Loc Le; Raymond T Damian; Roman F Wolf; Gary L White; David W Carey; Darrick Carter; Steven G Reed; Afzal A Siddiqui
Journal:  J Infect Dis       Date:  2014-01-16       Impact factor: 5.226

Review 8.  Development of a schistosomiasis vaccine.

Authors:  Adebayo J Molehin; Juan U Rojo; Sabrina Z Siddiqui; Sean A Gray; Darrick Carter; Afzal A Siddiqui
Journal:  Expert Rev Vaccines       Date:  2016-01-13       Impact factor: 5.217

9.  Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni.

Authors:  Workineh Torben; Gul Ahmad; Weidong Zhang; Stewart Nash; Loc Le; Souvik Karmakar; Afzal A Siddiqui
Journal:  Vaccine       Date:  2012-09-20       Impact factor: 3.641

10.  Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni.

Authors:  G Ahmad; W Torben; W Zhang; M Wyatt; A A Siddiqui
Journal:  Parasite Immunol       Date:  2009-03       Impact factor: 2.280
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