AIM: Evaluate the effect of intra and postoperative magnesium sulphate infusion on postoperative pain in abdominal surgery. METHODS: Prospective double-blind randomized controlled study. Forty eight patients were randomly allocated to receive in the induction of anaesthesia, intraoperatively and six hours postoperatively either magnesium sulphate M Group (bolus 50 mg/kg and 0.5 g/h) or placebo (P Group). Patients were given a dose of morphine (0.1 mg/kg) IV, 45 min before the end of surgery. Sedation, pain scores, cumulative morphine consumption and adverse effects were recorded up to 24 hours postoperatively. RESULTS: The duration of anaesthesia was similar in both groups. The time of the first demand of morphine was significantly longer in M Group then in P Group, respectively (18+/-5 min vs 7+/-1 min, p=0.03). Morphine consumption was significantly higher in control group than M group on the first postoperative day (52+/-4 mg vs 30+/-3 mg, p=0.0002). Pain scores were significantly lower in M group than in P group. Serum magnesium concentration was significantly higher in the M group. The frequency of side effects was similar in the two groups. CONCLUSION: The results of the study support magnesium sulphate as useful adjuvant for postoperative analgesia in abdominal surgery.
RCT Entities:
AIM: Evaluate the effect of intra and postoperative magnesium sulphate infusion on postoperative pain in abdominal surgery. METHODS: Prospective double-blind randomized controlled study. Forty eight patients were randomly allocated to receive in the induction of anaesthesia, intraoperatively and six hours postoperatively either magnesium sulphate M Group (bolus 50 mg/kg and 0.5 g/h) or placebo (P Group). Patients were given a dose of morphine (0.1 mg/kg) IV, 45 min before the end of surgery. Sedation, pain scores, cumulative morphine consumption and adverse effects were recorded up to 24 hours postoperatively. RESULTS: The duration of anaesthesia was similar in both groups. The time of the first demand of morphine was significantly longer in M Group then in P Group, respectively (18+/-5 min vs 7+/-1 min, p=0.03). Morphine consumption was significantly higher in control group than M group on the first postoperative day (52+/-4 mg vs 30+/-3 mg, p=0.0002). Pain scores were significantly lower in M group than in P group. Serum magnesium concentration was significantly higher in the M group. The frequency of side effects was similar in the two groups. CONCLUSION: The results of the study support magnesium sulphate as useful adjuvant for postoperative analgesia in abdominal surgery.