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Literature DB >> 19206287

Enzyme nanorings.

Tsui-Fen Chou¹, Christopher So, Brian R White, Jonathan C T Carlson, Mehmet Sarikaya, Carston R Wagner.

Abstract

We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins. The dimensions of the nanorings were found by static light scattering and atomic force microscopy studies to be dependent on the length and composition of the peptide linking the fusion proteins, ranging in size from 10 to 70 nm in diameter and 64 to 740 kDa. The catalytic efficiency of the nanorings was found to be dependent on ring size, thus suggesting that the arrangement of supermolecular assemblies of enzymes may be used to control their catalytic parameters.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 19206287 PMCID： PMC2682639 DOI： 10.1021/nn800577h

Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881

13 in total

Review 1. Molecular biomimetics: nanotechnology through biology.

Authors: Mehmet Sarikaya; Candan Tamerler; Alex K-Y Jen; Klaus Schulten; François Baneyx
Journal: Nat Mater Date: 2003-09 Impact factor: 43.841

2. Chemically controlled self-assembly of protein nanorings.

Authors: Jonathan C T Carlson; Sidhartha S Jena; Michelle Flenniken; Tsui-fen Chou; Ronald A Siegel; Carston R Wagner
Journal: J Am Chem Soc Date: 2006-06-14 Impact factor: 15.419

3. Materials and biology. Nanotechnology takes aim at cancer.

Authors: Robert F Service
Journal: Science Date: 2005-11-18 Impact factor: 47.728

4. Improved calculation of rotational diffusion and intrinsic viscosity of bead models for macromolecules and nanoparticles.

Authors: J García de la Torre; G del Rio Echenique; A Ortega
Journal: J Phys Chem B Date: 2007-02-08 Impact factor: 2.991

5. Designed protein-protein association.

Authors: Dirk Grueninger; Nora Treiber; Mathias O P Ziegler; Jochen W A Koetter; Monika-Sarah Schulze; Georg E Schulz
Journal: Science Date: 2008-01-11 Impact factor: 47.728

6. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.

Authors: Tsui-Fen Chou; Janina Baraniak; Renata Kaczmarek; Xin Zhou; Jilin Cheng; Brahma Ghosh; Carston R Wagner
Journal: Mol Pharm Date: 2007-01-12 Impact factor: 4.939

7. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.

Authors: Tsui-Fen Chou; Ilya B Tikh; Bruno A C Horta; Brahma Ghosh; Ricardo B De Alencastro; Carston R Wagner
Journal: J Biol Chem Date: 2007-03-02 Impact factor: 5.157

8. Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins.

Authors: Tsui-Fen Chou; Carston R Wagner
Journal: J Biol Chem Date: 2006-12-08 Impact factor: 5.157

9. 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.

Authors: Tsui-Fen Chou; Pawel Bieganowski; Kara Shilinski; Jilin Cheng; Charles Brenner; Carston R Wagner
Journal: J Biol Chem Date: 2005-02-09 Impact factor: 5.157

Enzyme nanorings.

Review 1. Molecular biomimetics: nanotechnology through biology.

2. Chemically controlled self-assembly of protein nanorings.

3. Materials and biology. Nanotechnology takes aim at cancer.

4. Improved calculation of rotational diffusion and intrinsic viscosity of bead models for macromolecules and nanoparticles.

5. Designed protein-protein association.

6. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.

7. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate.

8. Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins.

9. 31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.

10. Designing protein dimerizers: the importance of ligand conformational equilibria.

1. Chemically self-assembled antibody nanorings (CSANs): design and characterization of an anti-CD3 IgM biomimetic.

2. Generation of protein lattices by fusing proteins with matching rotational symmetry.

3. Protein interface remodeling in a chemically induced protein dimer.

4. In Vivo Evaluation of Site-Specifically PEGylated Chemically Self-Assembled Protein Nanostructures.

5. Domain-swapped cytochrome cb₅₆₂ dimer and its nanocage encapsulating a Zn-SO₄ cluster in the internal cavity.

Review 6. Hierarchical Self-Assembly of Proteins Through Rationally Designed Supramolecular Interfaces.

Review 7. Protein Assemblies: Nature-Inspired and Designed Nanostructures.