Literature DB >> 19206126

Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA.

Xiang Zheng1, Ulysses W Sallum, Sarika Verma, Humra Athar, Conor L Evans, Tayyaba Hasan.   

Abstract

A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of beta-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards beta-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the beta-lactam ring) releases the phototoxic component from the prodrug (see picture; Q = quencher).

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Year:  2009        PMID： 19206126     DOI： 10.1002/anie.200804804

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  17 in total

Review 1.  Development and applications of photo-triggered theranostic agents.

Authors:  Prakash Rai; Srivalleesha Mallidi; Xiang Zheng; Ramtin Rahmanzadeh; Youssef Mir; Stefan Elrington; Ahmat Khurshid; Tayyaba Hasan
Journal:  Adv Drug Deliv Rev       Date:  2010-09-19       Impact factor: 15.470

Review 2.  Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.

Authors:  Jonathan P Celli; Bryan Q Spring; Imran Rizvi; Conor L Evans; Kimberley S Samkoe; Sarika Verma; Brian W Pogue; Tayyaba Hasan
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

3.  Rapid, low-cost fluorescent assay of β-lactamase-derived antibiotic resistance and related antibiotic susceptibility.

Authors:  S Sibel Erdem; Shazia Khan; Akilan Palanisami; Tayyaba Hasan
Journal:  J Biomed Opt       Date:  2014       Impact factor: 3.170

Review 4.  Challenges and future in vaccines, drug development, and immunomodulatory therapy.

Authors:  Heather M Kling; Gerard J Nau; Ted M Ross; Thomas G Evans; Krishnendu Chakraborty; Kerry M Empey; JoAnne L Flynn
Journal:  Ann Am Thorac Soc       Date:  2014-08

5.  Guiding Empiric Treatment for Serious Bacterial Infections via Point of Care [Formula: see text]-Lactamase Characterization.

Authors:  Akilan Palanisami; Shazia Khan; Sultan Sibel Erdem; Tayyaba Hasan
Journal:  IEEE J Transl Eng Health Med       Date:  2016-06-29       Impact factor: 3.316

6.  Nonconventional Therapeutics against Staphylococcus aureus.

Authors:  Caroline M Grunenwald; Monique R Bennett; Eric P Skaar
Journal:  Microbiol Spectr       Date:  2018-11

7.  Rapid functional definition of extended spectrum β-lactamase activity in bacterial cultures via competitive inhibition of fluorescent substrate cleavage.

Authors:  Ulysses W Sallum; Xiang Zheng; Sarika Verma; Tayyaba Hasan
Journal:  Photochem Photobiol       Date:  2010-09-20       Impact factor: 3.421

8.  Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Authors:  Leanne B Josefsen; Ross W Boyle
Journal:  Theranostics       Date:  2012-10-04       Impact factor: 11.556

Review 9.  Antimicrobial photodynamic therapy for methicillin-resistant Staphylococcus aureus infection.

Authors:  Xiu-Jun Fu; Yong Fang; Min Yao
Journal:  Biomed Res Int       Date:  2013-02-28       Impact factor: 3.411

10.  Assay platform for clinically relevant metallo-β-lactamases.

Authors:  Sander S van Berkel; Jürgen Brem; Anna M Rydzik; Ramya Salimraj; Ricky Cain; Anil Verma; Raymond J Owens; Colin W G Fishwick; James Spencer; Christopher J Schofield
Journal:  J Med Chem       Date:  2013-08-16       Impact factor: 7.446
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