Literature DB >> 19204003

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.

Theo H van Dijk1, Aldo Grefhorst, Maaike H Oosterveer, Vincent W Bloks, Bart Staels, Dirk-Jan Reijngoud, Folkert Kuipers.   

Abstract

The farnesoid X receptor (FXR) is involved in regulation of bile acid and lipid metabolism. Recently, a role for FXR in control of glucose metabolism became evident. Because FXR is expressed along the length of the small intestine, we evaluated the potential role of FXR in glucose absorption and processing. During intravenous infusion of a trace amount of d-[6,6-(2)H(2)]glucose, a d-[U-(13)C]glucose-enriched oral glucose bolus was given, and glucose kinetics were determined in wild-type and Fxr(-/-) mice. Compared with wild-type mice, Fxr(-/-) mice showed a delayed plasma appearance of orally administered glucose. Multicompartmental kinetic modeling revealed that this delay was caused by an increased flux through the glucose 6-phosphate pool in enterocytes. Thus, our results show involvement of FXR in intestinal glucose absorption, representing a novel physiological function for this nuclear receptor.

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Year:  2009        PMID： 19204003      PMCID： PMC2667718          DOI： 10.1074/jbc.M807317200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  27 in total

1.  Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum.

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Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-18       Impact factor: 11.205

2.  Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

Authors:  Thierry Claudel; Ekkehard Sturm; Hélène Duez; Inés Pineda Torra; Audrey Sirvent; Vladimir Kosykh; Jean-Charles Fruchart; Jean Dallongeville; Dean W Hum; Folkert Kuipers; Bart Staels
Journal:  J Clin Invest       Date:  2002-04       Impact factor: 14.808

3.  Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.

Authors:  Aldo Grefhorst; Theo H van Dijk; Anke Hammer; Fjodor H van der Sluijs; Rick Havinga; Louis M Havekes; Johannes A Romijn; Pieter H Groot; Dirk-Jan Reijngoud; Folkert Kuipers
Journal:  Am J Physiol Endocrinol Metab       Date:  2005-06-07       Impact factor: 4.310

4.  Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

Authors:  T T Lu; M Makishima; J J Repa; K Schoonjans; T A Kerr; J Auwerx; D J Mangelsdorf
Journal:  Mol Cell       Date:  2000-09       Impact factor: 17.970

Review 5.  Bile acid regulation of gene expression: roles of nuclear hormone receptors.

Authors:  John Y L Chiang
Journal:  Endocr Rev       Date:  2002-08       Impact factor: 19.871

6.  Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

Authors:  Thierry Claudel; Yusuke Inoue; Olivier Barbier; Daniel Duran-Sandoval; Vladimir Kosykh; Jamila Fruchart; Jean-Charles Fruchart; Frank J Gonzalez; Bart Staels
Journal:  Gastroenterology       Date:  2003-08       Impact factor: 22.682

7.  Non-steady-state measurement of glucose turnover in rats by using a one-compartment model.

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Review 8.  The SLC2 family of facilitated hexose and polyol transporters.

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Journal:  Pflugers Arch       Date:  2003-05-16       Impact factor: 3.657

9.  Quantification of hepatic carbohydrate metabolism in conscious mice using serial blood and urine spots.

Authors:  Theo H van Dijk; Theo S Boer; Rick Havinga; Frans Stellaard; Folkert Kuipers; Dirk-Jan Reijngoud
Journal:  Anal Biochem       Date:  2003-11-01       Impact factor: 3.365

10.  Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

Authors:  Feike R van der Leij; Vincent W Bloks; Aldo Grefhorst; Jildou Hoekstra; Albert Gerding; Krista Kooi; Frans Gerbens; Gerard te Meerman; Folkert Kuipers
Journal:  Genomics       Date:  2007-10-22       Impact factor: 5.736
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  19 in total

Review 1.  Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs.

Authors:  Tiara R Ahmad; Rebecca A Haeusler
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Authors:  Valentina Tremaroli; Fredrik Bäckhed
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962

3.  Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study.

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Review 4.  Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.

Authors:  Geoffrey Porez; Janne Prawitt; Barbara Gross; Bart Staels
Journal:  J Lipid Res       Date:  2012-05-01       Impact factor: 5.922

5.  Continuous enteral administration can overcome the limited capacity to absorb glucose in rats with methotrexate-induced gastrointestinal mucositis.

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Journal:  Support Care Cancer       Date:  2012-09-26       Impact factor: 3.603

Review 6.  Nuclear bile acid signaling through the farnesoid X receptor.

Authors:  Claire Mazuy; Audrey Helleboid; Bart Staels; Philippe Lefebvre
Journal:  Cell Mol Life Sci       Date:  2014-12-16       Impact factor: 9.261

Review 7.  Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.

Authors:  Bart Staels; Vivian A Fonseca
Journal:  Diabetes Care       Date:  2009-11       Impact factor: 19.112

8.  Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

Authors:  Hollie I Swanson; Taira Wada; Wen Xie; Barbara Renga; Angela Zampella; Eleonora Distrutti; Stefano Fiorucci; Bo Kong; Ann M Thomas; Grace L Guo; Ramesh Narayanan; Muralimohan Yepuru; James T Dalton; John Y L Chiang
Journal:  Drug Metab Dispos       Date:  2012-10-04       Impact factor: 3.922

Review 9.  Farnesoid X Receptor an Emerging Target to Combat Obesity.

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Journal:  Dig Dis       Date:  2017-03-01       Impact factor: 2.404

Review 10.  Diet-microbiota interactions and personalized nutrition.

Authors:  Aleksandra A Kolodziejczyk; Danping Zheng; Eran Elinav
Journal:  Nat Rev Microbiol       Date:  2019-09-20       Impact factor: 60.633
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