| Literature DB >> 19203832 |
Wei Wang1, Elizabeth R Rayburn2, Yuqing Zhao3, Hui Wang4, Ruiwen Zhang5.
Abstract
We recently isolated and characterized two novel ginsenosides, 25-OH-PPD and 25-OCH(3)-PPD. We investigated whether these ginsenosides could represent safe and effective therapeutic agents for pancreatic cancer. In vitro and in vivo studies demonstrated that both compounds inhibited proliferation, caused cell cycle arrest, and induced apoptosis. They also both inhibited the growth of xenograft tumors without any host toxicity. Preliminary investigations into the mechanisms of action of the compounds suggest that their effects may be partially mediated by their inhibition of the MDM2 oncogene and related pathways. The data presented here support further evaluation of the ginsenosides for pancreatic cancer therapy.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19203832 PMCID： PMC2693424 DOI： 10.1016/j.canlet.2009.01.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679