Literature DB >> 19200023

Molecular modeling studies of ABC transporters involved in multidrug resistance.

Aina Westrheim Ravna1, Georg Sager.   

Abstract

Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

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Year:  2009        PMID： 19200023     DOI： 10.2174/138955709787316065

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  [Role of protein kinase D1 in regulating the growth, apoptosis and drug sensitivity of oral squamous carcinoma cells].

Authors:  Jing-Nan Wang; Ya-Ping Fan; Jiao Chen; Yun Feng; Bo-Miao Cui; Xiao-Ying Li; Li-Wei Wang; Hong-Li Chen; Ping Zhang; Hong-Kun Wu
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2019-12-01

2.  An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins.

Authors:  Meredith Hazen; Sunil Bhakta; Rajesh Vij; Steven Randle; Dara Kallop; Vicki Chiang; Isidro Hötzel; Bijay S Jaiswal; Karen E Ervin; Bing Li; Robby M Weimer; Paul Polakis; Richard H Scheller; Jagath R Junutula; Jo-Anne S Hongo
Journal:  MAbs       Date:  2014 Jan-Feb       Impact factor: 5.857

3.  Chemical Tumor Biology of Heparan Sulfate Proteoglycans.

Authors:  Karthik Raman; Balagurunathan Kuberan
Journal:  Curr Chem Biol       Date:  2010-01-01

4.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

5.  Specific MRP4 Inhibitor Ceefourin-1 Enhances Apoptosis Induced by 6-Mercaptopurine in Jurkat Leukemic Cells, but Not in Normal Lymphoblast Cell Line CRL-1991.

Authors:  Edgardo Becerra; Laura Berumen; Valeria Soto-Ontiveros; Guadalupe García-Alcocer
Journal:  Medicina (Kaunas)       Date:  2022-05-24       Impact factor: 2.948

6.  Methylation of SFRP5 is related to multidrug resistance in leukemia cells.

Authors:  H Wang; X Wang; R Hu; W Yang; A Liao; C Zhao; J Zhang; Z Liu
Journal:  Cancer Gene Ther       Date:  2014-01-17       Impact factor: 5.987

7.  Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression.

Authors:  Satish B Cheepala; Ju Bao; Deepa Nachagari; Daxi Sun; Yao Wang; Tao P Zhong; Tao Zhong; Anjaparavanda P Naren; Jie Zheng; John D Schuetz
Journal:  J Biol Chem       Date:  2013-06-13       Impact factor: 5.157

8.  Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children.

Authors:  Sok Kean Khoo; David Petillo; Mrutyunjaya Parida; Aik Choon Tan; James H Resau; Stephen K Obaro
Journal:  BMC Infect Dis       Date:  2011-09-13       Impact factor: 3.090

9.  Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics.

Authors:  Edgardo Becerra; Giovanny Aguilera-Durán; Laura Berumen; Antonio Romo-Mancillas; Guadalupe García-Alcocer
Journal:  Molecules       Date:  2021-02-17       Impact factor: 4.411

10.  Curcumol increases the sensitivity of colon cancer to 5-FU by regulating Wnt/β-catenin signaling.

Authors:  Jinfeng Gao; Daorong Hou; Ping Hu; Guoxin Mao
Journal:  Transl Cancer Res       Date:  2021-05       Impact factor: 1.241
  10 in total

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