| Literature DB >> 19198610 |
Daniel F Gudbjartsson1, Unnur S Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M Jonsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Valgerdur Steinthorsdottir, Hreinn Stefansson, Carolyn Williams, Jennie Hui, John Beilby, Nicole M Warrington, Alan James, Lyle J Palmer, Gerard H Koppelman, Andrea Heinzmann, Marcus Krueger, H Marike Boezen, Amanda Wheatley, Janine Altmuller, Hyoung Doo Shin, Soo-Taek Uh, Hyun Sub Cheong, Brynja Jonsdottir, David Gislason, Choon-Sik Park, Linda M Rasmussen, Celeste Porsbjerg, Jakob W Hansen, Vibeke Backer, Thomas Werge, Christer Janson, Ulla-Britt Jönsson, Maggie C Y Ng, Juliana Chan, Wing Yee So, Ronald Ma, Svati H Shah, Christopher B Granger, Arshed A Quyyumi, Allan I Levey, Viola Vaccarino, Muredach P Reilly, Daniel J Rader, Michael J A Williams, Andre M van Rij, Gregory T Jones, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Attilio Boner, Lydia Pescollderungg, Domenico Girelli, Oliviero Olivieri, Nicola Martinelli, Bjorn R Ludviksson, Dora Ludviksdottir, Gudmundur I Eyjolfsson, David Arnar, Gudmundur Thorgeirsson, Klaus Deichmann, Philip J Thompson, Matthias Wjst, Ian P Hall, Dirkje S Postma, Thorarinn Gislason, Jeffrey Gulcher, Augustine Kong, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Kari Stefansson.
Abstract
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).Entities:
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Year: 2009 PMID： 19198610 DOI： 10.1038/ng.323
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330