Literature DB >> 19197042

Comment on "Human-specific gain of function in a developmental enhancer".

Laurent Duret1, Nicolas Galtier.   

Abstract

Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by BGC, not positive selection.

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Year:  2009        PMID： 19197042     DOI： 10.1126/science.1165848

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

Review 1.  Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence.

Authors:  Patricia J Wittkopp; Gizem Kalay
Journal:  Nat Rev Genet       Date:  2011-12-06       Impact factor: 53.242

2.  Detecting positive selection within genomes: the problem of biased gene conversion.

Authors:  Abhirami Ratnakumar; Sylvain Mousset; Sylvain Glémin; Jonas Berglund; Nicolas Galtier; Laurent Duret; Matthew T Webster
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-08-27       Impact factor: 6.237

3.  Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.

Authors:  Sylvain Glémin
Journal:  Genetics       Date:  2010-04-26       Impact factor: 4.562

4.  Contrasts between adaptive coding and noncoding changes during human evolution.

Authors:  Ralph Haygood; Courtney C Babbitt; Olivier Fedrigo; Gregory A Wray
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-12       Impact factor: 11.205

Review 5.  Evolutionary dynamics of coding and non-coding transcriptomes.

Authors:  Anamaria Necsulea; Henrik Kaessmann
Journal:  Nat Rev Genet       Date:  2014-10-09       Impact factor: 53.242

6.  GC-biased evolution near human accelerated regions.

Authors:  Sol Katzman; Andrew D Kern; Katherine S Pollard; Sofie R Salama; David Haussler
Journal:  PLoS Genet       Date:  2010-05-20       Impact factor: 5.917

7.  Scanning for the signatures of positive selection for human-specific insertions and deletions.

Authors:  Chun-Hsi Chen; Trees-Juen Chuang; Ben-Yang Liao; Feng-Chi Chen
Journal:  Genome Biol Evol       Date:  2009-10-20       Impact factor: 3.416

8.  Ascertaining regions affected by GC-biased gene conversion through weak-to-strong mutational hotspots.

Authors:  Valer Gotea; Laura Elnitski
Journal:  Genomics       Date:  2014-04-13       Impact factor: 5.736

9.  Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots.

Authors:  Sol Katzman; John A Capra; David Haussler; Katherine S Pollard
Journal:  Genome Biol Evol       Date:  2011-06-21       Impact factor: 3.416

10.  The role of GC-biased gene conversion in shaping the fastest evolving regions of the human genome.

Authors:  Dennis Kostka; Melissa J Hubisz; Adam Siepel; Katherine S Pollard
Journal:  Mol Biol Evol       Date:  2011-11-10       Impact factor: 16.240
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