Literature DB >> 19196010

Evolution of the antibiotic resistance protein, FosA, is linked to a catalytically promiscuous progenitor.

Daniel W Brown1, Matthew R Schaab, William R Birmingham, Richard N Armstrong.   

Abstract

The fosfomycin (1) resistance proteins FosA and FosX in pathogenic microorganisms are related to a catalytically promiscuous progenitor encoded in a phn operon in Mesorhizobium loti. The mlr3345 gene product (FosX(Ml)) from M. loti has a very low epoxide hydrolase activity and even lower glutathione transferase activity toward 1 and does not confer resistance to the antibiotic. In vitro homologous recombination of the mlr3345 and pa1129 genes (a fosA gene from Pseudomonas aeruginosa that does confer robust resistance to 1) produces recombinant proteins that confer resistance to 1 and indicate that the FosA resistance proteins are functionally and genetically related to mlr3345.

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Year:  2009        PMID： 19196010      PMCID： PMC2756217          DOI： 10.1021/bi900078q

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  10 in total

Review 1.  Mechanistic diversity in a metalloenzyme superfamily.

Authors:  R N Armstrong
Journal:  Biochemistry       Date:  2000-11-14       Impact factor: 3.162

2.  Fosfomycin resistance proteins: a nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamily.

Authors:  Rachel E Rigsby; Kerry L Fillgrove; Lauren A Beihoffer; Richard N Armstrong
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

3.  Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabilization of beta-lactamase.

Authors:  Jochen Hecky; Kristian M Müller
Journal:  Biochemistry       Date:  2005-09-27       Impact factor: 3.162

4.  Rapid evolution of a protein in vitro by DNA shuffling.

Authors:  W P Stemmer
Journal:  Nature       Date:  1994-08-04       Impact factor: 49.962

5.  Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+).

Authors:  Chris L Rife; Rachel E Pharris; Marcia E Newcomer; Richard N Armstrong
Journal:  J Am Chem Soc       Date:  2002-09-18       Impact factor: 15.419

6.  Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms.

Authors:  Kerry L Fillgrove; Svetlana Pakhomova; Marcia E Newcomer; Richard N Armstrong
Journal:  J Am Chem Soc       Date:  2003-12-24       Impact factor: 15.419

7.  DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution.

Authors:  W P Stemmer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

8.  Phosphonomycin: structure and synthesis.

Authors:  B G Christensen; W J Leanza; T R Beattie; A A Patchett; B H Arison; R E Ormond; F A Kuehl; G Albers-Schonberg; O Jardetzky
Journal:  Science       Date:  1969-10-03       Impact factor: 47.728

9.  Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.

Authors:  Kerry L Fillgrove; Svetlana Pakhomova; Matthew R Schaab; Marcia E Newcomer; Richard N Armstrong
Journal:  Biochemistry       Date:  2007-06-13       Impact factor: 3.162

10.  A model for glutathione binding and activation in the fosfomycin resistance protein, FosA.

Authors:  Rachel E Rigsby; Daniel W Brown; Eric Dawson; Terry P Lybrand; Richard N Armstrong
Journal:  Arch Biochem Biophys       Date:  2007-05-14       Impact factor: 4.013
  10 in total
  4 in total

1.  Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .

Authors:  Derek Parsonage; Gerald L Newton; Robert C Holder; Bret D Wallace; Carleitta Paige; Chris J Hamilton; Patricia C Dos Santos; Matthew R Redinbo; Sean D Reid; Al Claiborne
Journal:  Biochemistry       Date:  2010-09-28       Impact factor: 3.162

2.  Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.

Authors:  Charlotte M Miton; Stefanie Jonas; Gerhard Fischer; Fernanda Duarte; Mark F Mohamed; Bert van Loo; Bálint Kintses; Shina C L Kamerlin; Nobuhiko Tokuriki; Marko Hyvönen; Florian Hollfelder
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-16       Impact factor: 11.205

3.  Characterization of the genomically encoded fosfomycin resistance enzyme from Mycobacterium abscessus.

Authors:  Skye Travis; Madeline R Shay; Shino Manabe; Nathaniel C Gilbert; Patrick A Frantom; Matthew K Thompson
Journal:  Medchemcomm       Date:  2019-09-27       Impact factor: 3.597

Review 4.  Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance.

Authors:  Alfredo Castañeda-García; Jesús Blázquez; Alexandro Rodríguez-Rojas
Journal:  Antibiotics (Basel)       Date:  2013-04-16
  4 in total

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