Literature DB >> 19195559

A system biology approach to understand functional activity of cell communication systems.

Julio Vera1, Olaf Wolkenhauer.   

Abstract

Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.

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Year:  2008        PMID： 19195559     DOI： 10.1016/S0091-679X(08)00817-0

Source DB:  PubMed          Journal:  Methods Cell Biol        ISSN： 0091-679X            Impact factor:   1.441


  9 in total

1.  From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer.

Authors:  Sarah S Knox
Journal:  Cancer Cell Int       Date:  2010-04-26       Impact factor: 5.722

2.  An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field.

Authors:  Johanna M Gostner; Oliver A Wrulich; Marcel Jenny; Dietmar Fuchs; Florian Ueberall
Journal:  BMC Complement Altern Med       Date:  2012-03-14       Impact factor: 3.659

3.  Eight paths of ERK1/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration.

Authors:  J W Li; G P Wang; J Y Fan; C F Chang; C S Xu
Journal:  J Genet       Date:  2011-12       Impact factor: 1.166

4.  Correlation analysis between gene expression profile of rat liver tissues and high-fat emulsion-induced nonalcoholic fatty liver.

Authors:  Cunshuan Xu; Gaiping Wang; Yunpeng Hao; Jia Zhi; Lianxing Zhang; Cuifang Chang
Journal:  Dig Dis Sci       Date:  2011-02-17       Impact factor: 3.199

5.  A model-based strategy to investigate the role of microRNA regulation in cancer signalling networks.

Authors:  Svetoslav Nikolov; Julio Vera; Ulf Schmitz; Olaf Wolkenhauer
Journal:  Theory Biosci       Date:  2010-08-31       Impact factor: 1.919

6.  Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach.

Authors:  Tselios C; Apostolos Zaravinos; Athanasios N Tsartsalis; Anna Tagka; Athanasios Kotoulas; Styliani A Geronikolou; Maria Braoudaki; George I Lambrou
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 7.  How variability in clinical phenotypes should guide research into disease mechanisms in asthma.

Authors:  Kian Fan Chung; Ian M Adcock
Journal:  Ann Am Thorac Soc       Date:  2013-12

Review 8.  Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection.

Authors:  Martina Cantone; Guido Santos; Pia Wentker; Xin Lai; Julio Vera
Journal:  Front Physiol       Date:  2017-08-30       Impact factor: 4.566

9.  Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling.

Authors:  Guido Santos; Xin Lai; Martin Eberhardt; Julio Vera
Journal:  Front Cell Infect Microbiol       Date:  2018-05-15       Impact factor: 5.293
  9 in total

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