Literature DB >> 19189224

Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies.

Anna Aviñó1, Sandra M Ocampo, Clara Caminal, José Carlos Perales, Ramon Eritja.   

Abstract

Oligoribonucleotide conjugates carrying nuclear localization peptide sequences at the 3'-end were prepared stepwise on a single support. The siRNA duplex carrying the nuclear localization peptide sequence at the 3'-end of the passenger strand has similar inhibitory properties as those of unmodified or cholesterol-modified RNA duplexes.

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Year:  2009        PMID： 19189224     DOI： 10.1007/s11030-009-9110-7

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  27 in total

1.  Gene silencing by systemic delivery of synthetic siRNAs in adult mice.

Authors:  Dag R Sørensen; Marianne Leirdal; Mouldy Sioud
Journal:  J Mol Biol       Date:  2003-04-04       Impact factor: 5.469

2.  Cell binding, uptake and cytosolic partition of HIV anti-gag phosphodiester oligonucleotides 3'-linked to cholesterol derivatives in macrophages.

Authors:  T LeDoan; F Etore; J P Tenu; Y Letourneux; S Agrawal
Journal:  Bioorg Med Chem       Date:  1999-11       Impact factor: 3.641

3.  Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus.

Authors:  M A Zanta; P Belguise-Valladier; J P Behr
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

4.  Synthesis of oligonucleotide-peptide conjugates carrying the c-myc peptide epitope as recognition system.

Authors:  Miriam Frieden; Anna Aviñó; Gema Tarrasón; Marta Escorihuela; Jaume Piulats; Ramon Eritja
Journal:  Chem Biodivers       Date:  2004-06       Impact factor: 2.408

Review 5.  Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA.

Authors:  Rudolph L Juliano
Journal:  Curr Opin Mol Ther       Date:  2005-04

6.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

Authors:  Jürgen Soutschek; Akin Akinc; Birgit Bramlage; Klaus Charisse; Rainer Constien; Mary Donoghue; Sayda Elbashir; Anke Geick; Philipp Hadwiger; Jens Harborth; Matthias John; Venkitasamy Kesavan; Gary Lavine; Rajendra K Pandey; Timothy Racie; Kallanthottathil G Rajeev; Ingo Röhl; Ivanka Toudjarska; Gang Wang; Silvio Wuschko; David Bumcrot; Victor Koteliansky; Stefan Limmer; Muthiah Manoharan; Hans-Peter Vornlocher
Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

Review 7.  Oligonucleotide analogs as antiviral agents.

Authors:  Martin M Fabani; John J Turner; Michael J Gait
Journal:  Curr Opin Mol Ther       Date:  2006-04

8.  Preparation and characterization of antisense oligonucleotide-peptide hybrids containing viral fusion peptides.

Authors:  S Soukchareun; G W Tregear; J Haralambidis
Journal:  Bioconjug Chem       Date:  1995 Jan-Feb       Impact factor: 4.774

9.  Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes.

Authors:  O Zelphati; E Wagner; L Leserman
Journal:  Antiviral Res       Date:  1994-09       Impact factor: 5.970

Review 10.  RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

Authors:  John J Turner; Simon Jones; Martin M Fabani; Gabriela Ivanova; Andrey A Arzumanov; Michael J Gait
Journal:  Blood Cells Mol Dis       Date:  2006-11-17       Impact factor: 3.039
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  2 in total

1.  Synthesis and in vitro inhibition properties of oligonucleotide conjugates carrying amphipathic proline-rich peptide derivatives of the sweet arrow peptide (SAP).

Authors:  Santiago Grijalvo; Ramon Eritja
Journal:  Mol Divers       Date:  2012-03-06       Impact factor: 2.943

2.  The synthesis of methylated, phosphorylated, and phosphonated 3'-aminoacyl-tRNA(Sec) mimics.

Authors:  Lukas Rigger; Rachel L Schmidt; Kaitlyn M Holman; Miljan Simonović; Ronald Micura
Journal:  Chemistry       Date:  2013-10-14       Impact factor: 5.236
  2 in total

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