| Literature DB >> 19188063 |
Teruyuki Nishimura1, Tomoharu Iino, Morihiro Mitsuya, Makoto Bamba, Hitomi Watanabe, Daisuke Tsukahara, Kenji Kamata, Kaori Sasaki, Sumika Ohyama, Hideka Hosaka, Mayumi Futamura, Yasufumi Nagata, Jun-Ichi Eiki.
Abstract
The identification and structure-activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19188063 DOI： 10.1016/j.bmcl.2009.01.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823