| Literature DB >> 19186072 |
Zaher K Otrock1, Hassan A Hatoum, Ahmad H Awada, Rim S Ishak, Ali I Shamseddine.
Abstract
Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a master regulator of oxygen and undergoes conformational changes in response to varying oxygen concentrations. In this paper, we review what has been described about HIF-1: its structure, its regulation and target genes, its role in cancer, and its implication for cancer therapy.Entities:
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Year: 2009 PMID： 19186072 DOI： 10.1016/j.critrevonc.2009.01.001
Source DB: PubMed Journal: Crit Rev Oncol Hematol ISSN： 1040-8428 Impact factor: 6.312