Literature DB >> 19181679

Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

Sarah Cohen-Woods1, Daria Gaysina, Nick Craddock, Anne Farmer, Joanna Gray, Cerisse Gunasinghe, Farzana Hoda, Lisa Jones, Jo Knight, Ania Korszun, Michael J Owen, Abram Sterne, Ian W Craig, Peter McGuffin.   

Abstract

It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19181679     DOI： 10.1093/hmg/ddp051

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  32 in total

1.  Genome-wide association study of comorbid depressive syndrome and alcohol dependence.

Authors:  Alexis C Edwards; Fazil Aliev; Laura J Bierut; Kathleen K Bucholz; Howard Edenberg; Victor Hesselbrock; John Kramer; Samuel Kuperman; John I Nurnberger; Marc A Schuckit; Bernice Porjesz; Danielle M Dick
Journal:  Psychiatr Genet       Date:  2012-02       Impact factor: 2.458

2.  Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression.

Authors:  Sabrina Bassi; Marianne L Seney; Pablo Argibay; Etienne Sibille
Journal:  J Psychiatr Res       Date:  2015-02-20       Impact factor: 4.791

3.  Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.

Authors:  Jennifer Joeyen-Waldorf; Yuliya S Nikolova; Nicole Edgar; Chris Walsh; Rama Kota; David A Lewis; Robert Ferrell; Stephen B Manuck; Ahmad R Hariri; Etienne Sibille
Journal:  Biol Psychiatry       Date:  2012-01-20       Impact factor: 13.382

4.  Lack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred mice.

Authors:  Ming Ding; Jennifer Arnold; Jeremy Turner; Vickram Ramkumar; Larry F Hughes; Rita A Trammell; Linda A Toth
Journal:  Comp Med       Date:  2010-08       Impact factor: 0.982

5.  Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

Authors:  Allan M Andersen; Robert H Pietrzak; Henry R Kranzler; Li Ma; Hang Zhou; Xiaoming Liu; John Kramer; Samuel Kuperman; Howard J Edenberg; John I Nurnberger; John P Rice; Jay A Tischfield; Alison Goate; Tatiana M Foroud; Jacquelyn L Meyers; Bernice Porjesz; Danielle M Dick; Victor Hesselbrock; Eric Boerwinkle; Steven M Southwick; John H Krystal; Myrna M Weissman; Douglas F Levinson; James B Potash; Joel Gelernter; Shizhong Han
Journal:  JAMA Psychiatry       Date:  2017-11-01       Impact factor: 21.596

6.  Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments.

Authors:  Kazuko Sakata; Abigail E Overacre
Journal:  J Neurochem       Date:  2017-08-16       Impact factor: 5.372

7.  CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.

Authors:  Silvia Jiménez-Morales; Juan Luis Jiménez-Ruíz; Blanca Estela Del Río-Navarro; Efraín Navarro-Olivos; Guillermo Escamilla-Guerrero; Ram Savan; Michael Dean; Lorena Orozco
Journal:  Mol Biol Rep       Date:  2014-01-16       Impact factor: 2.316

8.  Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder.

Authors:  Helen L Fisher; Sarah Cohen-Woods; Georgina M Hosang; Ania Korszun; Mike Owen; Nick Craddock; Ian W Craig; Anne E Farmer; Peter McGuffin; Rudolf Uher
Journal:  J Affect Disord       Date:  2012-07-25       Impact factor: 4.839

9.  Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.

Authors:  D M Cannon; J K Klaver; S K Gandhi; G Solorio; S A Peck; K Erickson; N Akula; J Savitz; W C Eckelman; M L Furey; B J Sahakian; F J McMahon; W C Drevets
Journal:  Mol Psychiatry       Date:  2010-03-30       Impact factor: 15.992

10.  Assessment of genetic and nongenetic interactions for the prediction of depressive symptomatology: an analysis of the Wisconsin Longitudinal Study using machine learning algorithms.

Authors:  Nicholas S Roetker; C David Page; James A Yonker; Vicky Chang; Carol L Roan; Pamela Herd; Taissa S Hauser; Robert M Hauser; Craig S Atwood
Journal:  Am J Public Health       Date:  2013-08-08       Impact factor: 9.308
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.