OBJECTIVE: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. MATERIALS AND METHODS: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. RESULTS: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. CONCLUSION: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
OBJECTIVE: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. MATERIALS AND METHODS: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. RESULTS: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. CONCLUSION: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
Authors: Richard J Reece; Maarten C Kraan; Aleksandra Radjenovic; Douglas J Veale; P J O'Connor; John P Ridgway; W W Gibbon; Ferdinand C Breedveld; Paul P Tak; Paul Emery Journal: Arthritis Rheum Date: 2002-02
Authors: Richard J Hodgson; Sylvia Connolly; Theresa Barnes; Brian Eyes; Robert S D Campbell; Robert Moots Journal: Magn Reson Med Date: 2007-09 Impact factor: 4.668
Authors: Wouter Stomp; Annemarie Krabben; Désirée van der Heijde; Tom W J Huizinga; Johan L Bloem; Mikkel Østergaard; Annette H M van der Helm-van Mil; Monique Reijnierse Journal: Eur Radiol Date: 2015-01-31 Impact factor: 5.315
Authors: Derk Frederik Matthaus Avenarius; Charlotte Nusman; Clara Malattia; Laura Tanturri de Horatio; Karen Rosendahl; Mario Maas; Lil-Sofie Ording Müller Journal: Pediatr Radiol Date: 2018-05-08