Literature DB >> 19171108

WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician?

Liesbet Lodewyckx1, Rik J U Lories.   

Abstract

Osteoporosis and osteoarthritis are common musculoskeletal disorders in which cause and outcome are determined by genetic and environmental factors. The WNT signaling pathway plays an important role in skeletal development and growth. Polymorphisms in a number of genes that belong to this pathway are associated with osteoarthritis and/or osteoporosis. This suggests a role for this molecular signaling pathway in postnatal joint and bone homeostasis and pathology. Increased activity of WNT signaling strengthens the bone but may have adverse effects on the articular cartilage. Frizzled related protein (FRZB) plays a role in both bone and cartilage. Better understanding of the WNT pathway and its modulators may lead to specific therapeutics for both osteoarthritis and osteoporosis. This review focuses on recent studies in human genetics and animal models and highlights the potential clinical relevance of this rapidly evolving field of research.

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Year:  2009        PMID： 19171108     DOI： 10.1007/s11926-009-0004-6

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  50 in total

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Authors:  Frederic Morvan; Kim Boulukos; Philippe Clément-Lacroix; Sergio Roman Roman; Isabelle Suc-Royer; Béatrice Vayssière; Patrick Ammann; Patrick Martin; Sonia Pinho; Philippe Pognonec; Patrick Mollat; Christof Niehrs; Roland Baron; Georges Rawadi
Journal:  J Bone Miner Res       Date:  2006-06       Impact factor: 6.741

Review 2.  Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors.

Authors:  Michael D Gordon; Roel Nusse
Journal:  J Biol Chem       Date:  2006-06-22       Impact factor: 5.157

3.  Assessment of linkage and association of 13 genetic loci with bone mineral density.

Authors:  Helen H L Lau; Mandy Y M Ng; William M W Cheung; Andrew D Paterson; Pak C Sham; Keith D K Luk; Vivian Chan; Annie W C Kung
Journal:  J Bone Miner Metab       Date:  2006       Impact factor: 2.626

4.  The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment.

Authors:  Kimihiko Sawakami; Alexander G Robling; Minrong Ai; Nathaniel D Pitner; Dawei Liu; Stuart J Warden; Jiliang Li; Peter Maye; David W Rowe; Randall L Duncan; Matthew L Warman; Charles H Turner
Journal:  J Biol Chem       Date:  2006-06-20       Impact factor: 5.157

5.  Global analyses of gene expression in early experimental osteoarthritis.

Authors:  C T G Appleton; V Pitelka; J Henry; F Beier
Journal:  Arthritis Rheum       Date:  2007-06

6.  LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Authors:  Y Gong; R B Slee; N Fukai; G Rawadi; S Roman-Roman; A M Reginato; H Wang; T Cundy; F H Glorieux; D Lev; M Zacharin; K Oexle; J Marcelino; W Suwairi; S Heeger; G Sabatakos; S Apte; W N Adkins; J Allgrove; M Arslan-Kirchner; J A Batch; P Beighton; G C Black; R G Boles; L M Boon; C Borrone; H G Brunner; G F Carle; B Dallapiccola; A De Paepe; B Floege; M L Halfhide; B Hall; R C Hennekam; T Hirose; A Jans; H Jüppner; C A Kim; K Keppler-Noreuil; A Kohlschuetter; D LaCombe; M Lambert; E Lemyre; T Letteboer; L Peltonen; R S Ramesar; M Romanengo; H Somer; E Steichen-Gersdorf; B Steinmann; B Sullivan; A Superti-Furga; W Swoboda; M J van den Boogaard; W Van Hul; M Vikkula; M Votruba; B Zabel; T Garcia; R Baron; B R Olsen; M L Warman
Journal:  Cell       Date:  2001-11-16       Impact factor: 41.582

7.  Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner.

Authors:  Elisheva Smith; Baruch Frenkel
Journal:  J Biol Chem       Date:  2004-11-10       Impact factor: 5.157

8.  Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice.

Authors:  Rika Nakanishi; Motoyuki Shimizu; Masayuki Mori; Haruhiko Akiyama; Shuzo Okudaira; Bungo Otsuki; Maiko Hashimoto; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
Journal:  J Bone Miner Res       Date:  2006-11       Impact factor: 6.741

9.  Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen.

Authors:  Gul Zaman; Helen L Jessop; Mariusz Muzylak; Roberto L De Souza; Andrew A Pitsillides; Joanna S Price; Lance L Lanyon
Journal:  J Bone Miner Res       Date:  2006-08       Impact factor: 6.741

Review 10.  Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship.

Authors:  Jan Dequeker; Jeroen Aerssens; Frank P Luyten
Journal:  Aging Clin Exp Res       Date:  2003-10       Impact factor: 3.636
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  9 in total

1.  Osteoarthritis as a whole joint disease.

Authors:  A Robin Poole
Journal:  HSS J       Date:  2012-02-23

2.  MicroRNA-1 Modulates Chondrocyte Phenotype by Regulating FZD7 of Wnt/ β-Catenin Signaling Pathway.

Authors:  Yang Yang; Yawei Wang; Haobo Jia; Bing Li; Dan Xing; Jiao Jiao Li
Journal:  Cartilage       Date:  2020-11-20       Impact factor: 3.117

3.  Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice.

Authors:  Liesbet Lodewyckx; Frédéric Cailotto; Sarah Thysen; Frank P Luyten; Rik J Lories
Journal:  Arthritis Res Ther       Date:  2012-01-20       Impact factor: 5.156

Review 4.  Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology.

Authors:  Bernard J Crespi; Matthew C Go
Journal:  Evol Med Public Health       Date:  2015-09-09

5.  The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity.

Authors:  Yusheng Li; Wenfeng Xiao; Minghua Sun; Zhenhan Deng; Chao Zeng; Hui Li; Tuo Yang; Liangjun Li; Wei Luo; Guanghua Lei
Journal:  Biomed Res Int       Date:  2016-07-31       Impact factor: 3.411

6.  Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

Authors:  Kentaro Miyamoto; Bisei Ohkawara; Mikako Ito; Akio Masuda; Akihiro Hirakawa; Tadahiro Sakai; Hideki Hiraiwa; Takashi Hamada; Naoki Ishiguro; Kinji Ohno
Journal:  PLoS One       Date:  2017-09-19       Impact factor: 3.240

7.  Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes.

Authors:  Silvia Díaz-Prado; Claudia Cicione; Emma Muiños-López; Tamara Hermida-Gómez; Natividad Oreiro; Carlos Fernández-López; Francisco J Blanco
Journal:  BMC Musculoskelet Disord       Date:  2012-08-12       Impact factor: 2.362

Review 8.  Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis.

Authors:  Ashish R Sharma; Supriya Jagga; Sang-Soo Lee; Ju-Suk Nam
Journal:  Int J Mol Sci       Date:  2013-09-30       Impact factor: 5.923

9.  A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway.

Authors:  Yang Yang; Dan Xing; Yawei Wang; Haobo Jia; Bing Li; Jiao Jiao Li
Journal:  BMC Mol Cell Biol       Date:  2020-07-10
  9 in total

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