Literature DB >> 19168985

Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.

Mi-Jin Sohn1, Chang-Ji Zheng, Won-Gon Kim.   

Abstract

In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound macrolactin B, has been isolated from the mycelium of liquid fermentation cultures of Bacillus sp. AT28. The structure of macrolactin S was determined on the basis of MS and NMR data. Macrolactin S showed a dose-dependent inhibition of Staphylococcus aureus FabG, not inhibiting S. aureus FabI. Also macrolactin S inhibited the growth of S. aureus, Bacillus subtilis, and Escherichia coli.

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Year:  2008        PMID： 19168985     DOI： 10.1038/ja.2008.98

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

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10.  Tachyplesin Causes Membrane Instability That Kills Multidrug-Resistant Bacteria by Inhibiting the 3-Ketoacyl Carrier Protein Reductase FabG.

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